Impact of Nocturia on Mortality: The Nagahama Study
2020; Lippincott Williams & Wilkins; Volume: 204; Issue: 5 Linguagem: Inglês
10.1097/ju.0000000000001138
ISSN1527-3792
AutoresSatoshi Funada, Yasuharu Tabara, Kazuya Setoh, Hiromitsu Negoro, Shusuke Akamatsu, Takayuki Yoshino, Koji Yoshimura, Norio Watanabe, Toshi A. Furukawa, Fumihiko Matsuda, Osamu Ogawa,
Tópico(s)Bladder and Urothelial Cancer Treatments
ResumoNo AccessJournal of UrologyAdult Urology1 Nov 2020Impact of Nocturia on Mortality: The Nagahama StudyThis article is commented on by the following:Editorial Comment Satoshi Funada, Yasuharu Tabara, Kazuya Setoh, Hiromitsu Negoro, Shusuke Akamatsu, Takayuki Yoshino, Koji Yoshimura, Norio Watanabe, Toshi A. Furukawa, Fumihiko Matsuda, and Osamu Ogawa Satoshi FunadaSatoshi Funada Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan Department of Health Promotion and Human Behavior, Kyoto University School of Public Health, Kyoto, Japan More articles by this author , Yasuharu TabaraYasuharu Tabara Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author , Kazuya SetohKazuya Setoh Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author , Hiromitsu NegoroHiromitsu Negoro Department of Urology, University of Tsukuba Hospital, Ibaraki, Japan More articles by this author , Shusuke AkamatsuShusuke Akamatsu Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author , Takayuki YoshinoTakayuki Yoshino Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author , Koji YoshimuraKoji Yoshimura Department of Urology, Shizuoka General Hospital, Shizuoka, Japan More articles by this author , Norio WatanabeNorio Watanabe Department of Health Promotion and Human Behavior, Kyoto University School of Public Health, Kyoto, Japan More articles by this author , Toshi A. FurukawaToshi A. Furukawa Department of Health Promotion and Human Behavior, Kyoto University School of Public Health, Kyoto, Japan Financial interest and/or other relationship with Meiji, Mitsubishi-Tanabe, MSD and Pfizer, as well as a patent (2018-177688) pending. More articles by this author , Fumihiko MatsudaFumihiko Matsuda Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author , and Osamu OgawaOsamu Ogawa †Correspondence: Department of Urology, Kyoto University Graduate School of Medicine, 54, Shogoinkawahara-cho, Sakyo-ku Kyoto606-8507, Japan telephone: +81 75 751 3325; FAX: +81 75 761 3441; E-mail Address: [email protected] Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author for the Nagahama Study Group View All Author Informationhttps://doi.org/10.1097/JU.0000000000001138AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Nocturia has been reported as a risk factor for mortality. However, evidence is limited and has a high risk of bias. We evaluated the association between nocturia and mortality using longitudinal data from the general Japanese population. Materials and Methods: Data were obtained from the Nagahama Cohort Project, a longitudinal, general population cohort study. Nocturia was measured using the International Prostate Symptom Score. Mortality data were obtained from the Basic Resident Register in Nagahama City. We used Cox proportional hazard models and time-varying covariates at baseline and 5-year followup to analyze the association between nocturia and mortality. Results: We analyzed 9,762 participants (median age 56.8 years, male 32.8%). The prevalence rates of nocturnal voiding at 0, 1, 2 and 3 or more times were 44.3%, 39.1%, 11.7% and 4.9%, respectively. A total of 263 participants died. Followup assessment was performed 3,224 (SD 537) days after baseline. According to multivariable Cox proportional hazard regressions, mortality increased dose dependently with the nocturnal voiding frequency as HR 1.46 for 1 time (95% CI 1.02–2.09), HR 1.85 for 2 times (95% CI 1.23–2.77) and HR 2.06 (95% CI 1.28–3.32) for 3 or more times in comparison with 0 times (p for trend=0.00084). In the time varying Cox proportional hazard regression the association was still significant (p for trend=0.0017). Conclusions: According to this longitudinal study with a low incidence of missing data and high representation of the general population, nocturia is associated with mortality. REFERENCES 1. : International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. Neurourol Urodyn 2019; 8: 499. Google Scholar 2. : The prevalence and causes of nocturia. J Urol 2013; 189: S86. Link, Google Scholar 3. : What is the most bothersome lower urinary tract symptom? 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Accessed February 12, 2020. Google Scholar No direct or indirect commercial, personal, academic, political, religious or ethical incentive is associated with publishing this article. The Nagahama study was supported by a university grant, the Center of Innovation Program, the Global University Project, and a Grant-in-Aid for Scientific Research (25293141, 26670313, 26293198, 17H04182, 17H04126, 17H04123, 18K18450) from the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Practical Research Project for Rare/Intractable Diseases (ek0109070, ek0109070, ek0109196, ek0109348), the Comprehensive Research on Aging and Health Science Research Grants for Dementia R&D (dk0207006, dk0207027), the Program for an Integrated Database of Clinical and Genomic Information (kk0205008), the Practical Research Project for Lifestyle-related Diseases including Cardiovascular Diseases and Diabetes Mellitus (ek0210066, ek0210096, ek0210116), and the Research Program for Health Behavior Modification by Utilizing IoT (le0110005), from Japan Agency for Medical Research and Development (AMED); the Takeda Medical Research Foundation; the Mitsubishi Foundation; the Daiwa Securities Health Foundation; and the Sumitomo Foundation. © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsRelated articlesJournal of Urology4 Sep 2020Editorial Comment Volume 204Issue 5November 2020Page: 996-1002Supplementary Materials Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.Keywordscohort studiesnocturiamortalitylongitudinal studiesAcknowledgmentsThe Nagahama City Office and the nonprofit organization Zeroji Club provided assistance conducting the Nagahama Study. The Nagahama Study Group executive committee is composed of the following individuals: Yasuharu Tabara, Takahisa Kawaguchi, Kazuya Setoh, Yoshimitsu Takahashi, Shinji Kosugi, Takeo Nakayama and Fumihiko Matsuda from the Center for Genomic Medicine, Kyoto University Graduate School of Medicine (YaT, TK, KS, FM); the Department of Health Informatics (YoT, TN) and the Department of Medical Ethics and Medical Genetics (SK), Kyoto University School of Public Health.MetricsAuthor Information Satoshi Funada Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan Department of Health Promotion and Human Behavior, Kyoto University School of Public Health, Kyoto, Japan More articles by this author Yasuharu Tabara Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author Kazuya Setoh Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author Hiromitsu Negoro Department of Urology, University of Tsukuba Hospital, Ibaraki, Japan More articles by this author Shusuke Akamatsu Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author Takayuki Yoshino Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author Koji Yoshimura Department of Urology, Shizuoka General Hospital, Shizuoka, Japan More articles by this author Norio Watanabe Department of Health Promotion and Human Behavior, Kyoto University School of Public Health, Kyoto, Japan More articles by this author Toshi A. Furukawa Department of Health Promotion and Human Behavior, Kyoto University School of Public Health, Kyoto, Japan Financial interest and/or other relationship with Meiji, Mitsubishi-Tanabe, MSD and Pfizer, as well as a patent (2018-177688) pending. More articles by this author Fumihiko Matsuda Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author Osamu Ogawa Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan †Correspondence: Department of Urology, Kyoto University Graduate School of Medicine, 54, Shogoinkawahara-cho, Sakyo-ku Kyoto606-8507, Japan telephone: +81 75 751 3325; FAX: +81 75 761 3441; E-mail Address: [email protected] More articles by this author Expand All No direct or indirect commercial, personal, academic, political, religious or ethical incentive is associated with publishing this article. The Nagahama study was supported by a university grant, the Center of Innovation Program, the Global University Project, and a Grant-in-Aid for Scientific Research (25293141, 26670313, 26293198, 17H04182, 17H04126, 17H04123, 18K18450) from the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Practical Research Project for Rare/Intractable Diseases (ek0109070, ek0109070, ek0109196, ek0109348), the Comprehensive Research on Aging and Health Science Research Grants for Dementia R&D (dk0207006, dk0207027), the Program for an Integrated Database of Clinical and Genomic Information (kk0205008), the Practical Research Project for Lifestyle-related Diseases including Cardiovascular Diseases and Diabetes Mellitus (ek0210066, ek0210096, ek0210116), and the Research Program for Health Behavior Modification by Utilizing IoT (le0110005), from Japan Agency for Medical Research and Development (AMED); the Takeda Medical Research Foundation; the Mitsubishi Foundation; the Daiwa Securities Health Foundation; and the Sumitomo Foundation. 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