Portal de Periódicos da CAPES

Transcriptional and Cellular Diversity of the Human Heart

2020; Lippincott Williams & Wilkins; Volume: 142; Issue: 5 Linguagem: Inglês

10.1161/circulationaha.119.045401

1524-4539

Nathan R. Tucker, Mark Chaffin, Stephen J. Fleming, Amelia Weber Hall, Victoria A. Parsons, Kenneth Bedi, Amer-Denis Akkad, Caroline N. Herndon, Alessandro Arduini, Irinna Papangeli, Carolina Roselli, François Aguet, Seung Hoan Choi, Kristin Ardlie, Mehrtash Babadi, Kenneth B. Margulies, Christian M. Stegmann, Patrick T. Ellinor,

Single-cell and spatial transcriptomics

The human heart requires a complex ensemble of specialized cell types to perform its essential function. A greater knowledge of the intricate cellular milieu of the heart is critical to increase our understanding of cardiac homeostasis and pathology. As recent advances in low-input RNA sequencing have allowed definitions of cellular transcriptomes at single-cell resolution at scale, we have applied these approaches to assess the cellular and transcriptional diversity of the nonfailing human heart.