A brief note on randomized controlled trials and compassionate/off-label use of drugs in the early phases of the COVID-19 pandemic
2020; BioExcel Publishing Ltd; Volume: 9; Linguagem: Inglês
10.7573/dic.2020-5-2
ISSN1745-1981
AutoresMatteo Bassetti, Paolo Pelosi, Chiara Robba, Antonio Vena, Daniele Roberto Giacobbe,
Tópico(s)Long-Term Effects of COVID-19
ResumoRandomized controlled trials (RCTs) are the best way to find effective and acceptable safe treatments for COVID-19 and any possible future outbreak. However, caution is needed when comparing the number of participants in RCTs with that of patients with COVID-19 treated with compassionate and/or off-label drugs to support the hypothesis that the latter are preferred by clinicians as an alternative to the former.
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