Portal de Periódicos da CAPES

SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes

2020; Cold Spring Harbor Laboratory; Linguagem: Inglês

10.1101/2020.05.19.20105460

NSN Graham, Cornelia Junghans, R. Downes, C Sendall, Helen Lai, A. McKirdy, Paul Elliott, Robert Howard, David Wingfield, Max Priestman, Marta Ciechonska, Loren Cameron, Maria K. Storch, MA Crone, P. S. Freemont, Paul Randell, Robert H. McLaren, Nicola Lang, Shamez Ladhani, Frances Sanderson, David Sharp,

COVID-19 and Mental Health

ABSTRACT Objectives To understand SARS-Co-V-2 infection and transmission in UK nursing homes in order to develop preventive strategies for protecting the frail elderly residents. Design An outbreak investigation. Setting 4 nursing homes affected by COVID-19 outbreaks in central London. Participants 394 residents and 70 staff in nursing homes. Interventions Two point-prevalence surveys one week apart where residents underwent SARS-CoV-2 testing and had relevant symptoms documented. Asymptomatic staff from three of the four homes were also offered SARS-CoV-2 testing. Main outcome measures All-cause mortality, and mortality attributed to COVID-19 on death certificates. Prevalence of SARS-CoV-2 infection and symptoms in residents and staff. Results Overall, 26% (95% confidence interval 22 to 31) of residents died over the two-month period. All-cause mortality increased by 203% (95% CI 70 to 336). Systematic testing identified 40% (95% CI 35 to 46) of residents, of whom 43% (95% CI 34 to 52) were asymptomatic and 18% (95% CI 11 to 24) had atypical symptoms, as well as 4% (95% CI -1 to 9) of asymptomatic staff who tested positive for SARS-CoV-2. Conclusions The SARS-CoV-2 outbreak was associated with a very high mortality rate in residents of nursing homes. Systematic testing of all residents and a representative sample of staff identified high rates of SARS-CoV-2 positivity across the four nursing homes, highlighting a potential for regular screening to prevent future outbreaks.