Produção Nacional
Revisado por pares
Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection
2020; American Society for Microbiology; Volume: 64; Issue: 8 Linguagem: Inglês
10.1128/aac.02497-19
ISSN1098-6596
AutoresYara Almeida Machado, Maria Terezinha Bahia, Ivo Santana Caldas, Ana Lia Mazzeti, Rômulo Dias Novaes, Breno Raimundo Vilas Boas, Lorena Júnia de Souza Santos, Olindo Assis Martins-Filho, Marcos José Marques, Lívia de Figueiredo Diniz,
Tópico(s)Research on Leishmaniasis Studies
ResumoMining existing agents that enhance the therapeutic potential of ergosterol biosynthesis inhibitors (EBI) is a promising approach to improve Chagas disease chemotherapy. In this study, we evaluated the effect of ravuconazole, an EBI, combined with amlodipine, a calcium channel blocker, upon Trypanosoma cruzi experimental infection. In vitro assays confirmed the trypanocidal activity of both compounds in monotherapy and demonstrated an additive effect (sum of the fractional inhibitory concentration [ΣFIC] > 0.
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