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Coronaviridae—Old friends, new enemy!

2020; Wiley; Volume: 28; Issue: S1 Linguagem: Inglês

10.1111/odi.13447

1601-0825

Jair Carneiro Leão, TERESA PAULA DE LIMA GUSMÃO, ADRIANA MACHADO ZARZAR, Jair Carneiro Leão Filho, ANDREZA BARKOKEBAS SANTOS DE FARIA, Igor Henrique Morais Silva, Luiz Alcino Gueiros, Narendran Andrew Robinson, Stephen Porter, Alessandra de Albuquerque Tavares Carvalho,

Animal Virus Infections Studies

Coronaviridae is a family of single-stranded positive enveloped RNA viruses. This article aimed to review the history of these viruses in the last 60 years since their discovery to understand what lessons can be learned from the past. A review of the PubMed database was carried out, describing taxonomy, classification, virology, genetic recombination, host adaptation, and main symptoms related to each type of virus. SARS-CoV-2 is responsible for the ongoing global pandemic, and SARS-CoV and MERS-CoV were responsible for causing severe respiratory illness and regional epidemics in the past while the four other strains of CoVs (229-E OC43, NL63, and HKU1) circulate worldwide and normally only cause mild upper respiratory tract infections. Given the enormous diversity of coronavirus viruses in wildlife and their continuous evolution and adaptation to humans, future outbreaks would undoubtedly occur. Restricting or banning all trade in wild animals in wet markets would be a necessary measure to reduce future zoonotic infections.