The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells
2020; American Association for the Advancement of Science; Volume: 13; Issue: 634 Linguagem: Inglês
10.1126/scisignal.aaz1053
ISSN1937-9145
AutoresCesar A. Corzo, Eugene Varfolomeev, Audi Setiadi, Ross Francis, Sha Klabunde, Kate Senger, Swathi Sujatha-Bhaskar, Joy Drobnick, Steven Do, Eric Suto, Zhiyu Huang, Jeffrey Eastham‐Anderson, Arna Katewa, Jodie Pang, Melanie Domeyer, Christopher Dela Cruz, Andrés Paler-Martı́nez, Vivian Wing Chong Lau, Azadeh Hadadianpour, Vladimir Ramirez-Carrozi, Yonglian Sun, Katherine Bao, Daqi Xu, Emily Hunley, Hans D. Brightbill, Søren Warming, Merone Roose‐Girma, Alfred Wong, Lucinda Tam, Claire Emson, James J. Crawford, Wendy B. Young, Rajita Pappu, Brent S. McKenzie, Vida Asghari, Domagoj Vucic, Jason A. Hackney, Cary D. Austin, Wyne P. Lee, Annemarie Lekkerkerker, Nico Ghilardi, Marian C. Bryan, James R. Kiefer, Michael J. Townsend, Ali A. Zarrin,
Tópico(s)T-cell and B-cell Immunology
ResumoInhibiting the kinase IRAK4 may suppress a multicellular autoinflammatory loop in patients with lupus.
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