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BIBTEX RIS

Tenofovir Disoproxil Fumarate: New Chemical Developments and Encouraging in vitro Biological Results for SARS-CoV-2

2020; Brazilian Chemical Society; Linguagem: Inglês

10.21577/0103-5053.20200106

ISSN

1678-4790

Autores

Giuliano C. Clososki, Rafael A. Soldi, Rodrigo Moreira da Silva, Thais Guaratini, José Lopes, Pâmela R. R. Pereira, João Lopes, Thiago dos Santos, Ronaldo B. Martins, Cristina Costa, Andréia de Carvalho, Luis L. P. daSilva, Eurico Arruda, Norberto Peporine Lopes,

Tópico(s)

SARS-CoV-2 detection and testing

Resumo

The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led society to live with a serious public health problem.In this sense, repositioning of antiretrovirals has captured the attention of the scientific community.Tenofovir disoproxil fumarate (TDF) is an antiretroviral compound that is used to treat acquired immune deficiency syndrome (AIDS) and hepatitis B. In this short report, we present a scale-up investigation of TDF by in situ infrared spectroscopy monitoring and a forced degradation study to describe a new degradation product.Finally, we have evaluated TDF in vitro for SARS-CoV-2 for the first time foreseeing the using of this medicine in pre-clinical and clinical investigations for the COVID-19 (coronavirus disease 2019) treatment.

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