Synthesis of New Pt(II) Complex Bearing Organoselenium Ligands and Evaluation of Cytotoxic Activity of Some Structurally Related Pd(II) Complexes
2020; Volume: 39; Issue: 1 Linguagem: Inglês
10.20450/mjcce.2020.1905
ISSN1857-5625
AutoresNinko Radenković, Marina D. Kostić, Nataša Đorđević, Zana Dolićanin, Tanja Soldatović, Marko Živanović, Vera M. Divac,
Tópico(s)Synthesis of Tetrazole Derivatives
ResumoHerein we report the synthesis of new trans-bis(2-phenylselenylmethyl)oxolane)dichloroplatinum(II) complex Pt1. Newly synthetized complex, together with two, structurally related trans-Pd(II) complexes (trans-bis(2-(phenylselenylmethyl)oxolane)dichloropalladium(II) Pd1 and trans-bis(2-(phenylselenylmethyl)oxane)dichloropalladium(II)) Pd2, were screened for cytotoxic activity through in vitro study on the HCT-116 colorectal carcinoma cell line and on the MRC-5 healthy lung pleura cell line. Activity of complexes was assessed by comparing it to the cisplatin. The cells viability and proliferation were determined using MTT assay.
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