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Structural characterization, antibacterial activity and NorA efflux pump inhibition of flavonoid fisetinidol

2020; Elsevier BV; Volume: 132; Linguagem: Inglês

10.1016/j.sajb.2020.03.023

1727-9321

Horlando Carlota da Silva, Antônio Linkoln Alves Borges Leal, Mauro Macêdo de Oliveira, Humberto Medeiros Barreto, Henrique Douglas Melo Coutinho, Hélcio Silva dos Santos, Gilvandete M. P. Santiago, Thiago Sampaio de Freitas, Igor Kleber Campos Lima, Alexandre Magno Rodrigues Teixeira, C.E.S. Nogueira,

Ginseng Biological Effects and Applications

Flavonoids belong to the extensive group of polyphenols and have several biological activities such as anti-inflammatory, anti-ulcer, anticancer, antiviral, antibacterial, and antispasmodic. These compounds can thus be explored as a tool against multidrug resistant bacteria, as nosocomial infections now constitute a major public health problem worldwide. We have carried out a structural characterization by nuclear magnetic resonance and FT-IR of fisetinidol, a flavonoid isolated from B. pentandra stems. In addition, this flavonoid was tested for antibacterial and modulatory activities, as well as inhibition of the NorA efflux pump. Fisetinidol has no intrinsic antibacterial activity. However, there is synergism in association with norfloxacin, with a two-fold decrease in MIC. When compared to chlorpromazine, a standard efflux pump inhibitor, a two-fold decrease in MIC was also verified when used against S. aureus SA-1199B, which over expresses the NorA gene encoding the NorA efflux protein. As such, it could become an alternative source to reverse the bacterial resistance if administered in association with antibiotics.