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Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study

2020; BMJ; Volume: 75; Issue: 9 Linguagem: Inglês

10.1136/thoraxjnl-2019-214461

1468-3296

Michaela R. Anderson, Imaani Easthausen, Grace Gallagher, Jayaram K. Udupa, Yubing Tong, Drew A. Torigian, Joshua M. Diamond, Mary K. Porteous, Scott M. Palmer, Laurie D. Snyder, Luke Benvenuto, Meghan Aversa, Selim M. Arcasoy, John R. Greenland, Steven R. Hays, Jasleen Kukreja, Edward Cantu, John S. Kim, Dympna Gallagher, Matthew R. Baldwin, R. Graham Barr, David J. Lederer, Jason D. Christie, Jonathan P. Singer,

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was associated with 14 m decrease in 6MWD (95% CI −20 to −8) and 20% increased risk of death or delisting (95% CI 10% to 40%). Each ½-standard deviation decrease in thigh muscle attenuation was associated with 15 m decrease in 6MWD (95% CI −21 to −10). CT imaging may improve candidate risk stratification.