Incidence and determinants of QT interval prolongation in COVID‐19 patients treated with hydroxychloroquine and azithromycin
2020; Wiley; Volume: 31; Issue: 8 Linguagem: Inglês
10.1111/jce.14594
ISSN1540-8167
AutoresIlir Maraj, James P. Hummel, Roy Taoutel, Romy Chamoun, Virginia Workman, Cindy Li, Lydia Tran, Alexander Delvecchio, Christopher Howes, Joseph G. Akar,
Tópico(s)ECG Monitoring and Analysis
ResumoJournal of Cardiovascular ElectrophysiologyVolume 31, Issue 8 p. 1904-1907 BRIEF COMMUNICATION Incidence and determinants of QT interval prolongation in COVID-19 patients treated with hydroxychloroquine and azithromycin Ilir Maraj MD, Ilir Maraj MD Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut Department of Internal Medicine, Greenwich Hospital, Greenwich, ConnecticutSearch for more papers by this authorJames P. Hummel MD, James P. Hummel MD orcid.org/0000-0003-3081-0277 Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, ConnecticutSearch for more papers by this authorRoy Taoutel MD, Roy Taoutel MD Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, ConnecticutSearch for more papers by this authorRomy Chamoun MD, Romy Chamoun MD Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, ConnecticutSearch for more papers by this authorVirginia Workman MD, Virginia Workman MD Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, ConnecticutSearch for more papers by this authorCindy Li BS, Cindy Li BS Department of Pharmacy Services, Yale New Haven Hospital, New Haven, ConnecticutSearch for more papers by this authorLydia Tran PharmD, Lydia Tran PharmD orcid.org/0000-0002-6315-5435 Department of Pharmacy Services, Yale New Haven Hospital, New Haven, ConnecticutSearch for more papers by this authorAlexander DelVecchio MD, Alexander DelVecchio MD Department of Internal Medicine, Greenwich Hospital, Greenwich, ConnecticutSearch for more papers by this authorChristopher Howes MD, Christopher Howes MD Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut Department of Internal Medicine, Greenwich Hospital, Greenwich, ConnecticutSearch for more papers by this authorJoseph G. Akar MD, PhD, Corresponding Author Joseph G. Akar MD, PhD [email protected] orcid.org/0000-0002-9348-3763 Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut Department of Internal Medicine, Greenwich Hospital, Greenwich, Connecticut Correspondence Joseph G. Akar, MD, PhD, Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, Dana 3, 789 Howard Ave, New Haven, CT 06520. Email: [email protected]Search for more papers by this author Ilir Maraj MD, Ilir Maraj MD Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut Department of Internal Medicine, Greenwich Hospital, Greenwich, ConnecticutSearch for more papers by this authorJames P. Hummel MD, James P. Hummel MD orcid.org/0000-0003-3081-0277 Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, ConnecticutSearch for more papers by this authorRoy Taoutel MD, Roy Taoutel MD Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, ConnecticutSearch for more papers by this authorRomy Chamoun MD, Romy Chamoun MD Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, ConnecticutSearch for more papers by this authorVirginia Workman MD, Virginia Workman MD Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, ConnecticutSearch for more papers by this authorCindy Li BS, Cindy Li BS Department of Pharmacy Services, Yale New Haven Hospital, New Haven, ConnecticutSearch for more papers by this authorLydia Tran PharmD, Lydia Tran PharmD orcid.org/0000-0002-6315-5435 Department of Pharmacy Services, Yale New Haven Hospital, New Haven, ConnecticutSearch for more papers by this authorAlexander DelVecchio MD, Alexander DelVecchio MD Department of Internal Medicine, Greenwich Hospital, Greenwich, ConnecticutSearch for more papers by this authorChristopher Howes MD, Christopher Howes MD Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut Department of Internal Medicine, Greenwich Hospital, Greenwich, ConnecticutSearch for more papers by this authorJoseph G. Akar MD, PhD, Corresponding Author Joseph G. Akar MD, PhD [email protected] orcid.org/0000-0002-9348-3763 Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut Department of Internal Medicine, Greenwich Hospital, Greenwich, Connecticut Correspondence Joseph G. Akar, MD, PhD, Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, Dana 3, 789 Howard Ave, New Haven, CT 06520. Email: [email protected]Search for more papers by this author First published: 02 June 2020 https://doi.org/10.1111/jce.14594Citations: 24 Ilir Maraj and James P. Hummel contributed equally to this study. Disclosures: No relationships with industry to be disclosed related to this specific work. Joseph Akar reports consulting for Biosense Webster. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1Gollob MH. COVID-19, clinical trials and QT-prolonging prophylactic therapy in healthy subjects: first, do no harm. J Am Coll Cardiol. 2020; 20: 79. https://doi.org/10.1016/j.jacc.2020.05.008 Google Scholar 2Mercuro NJ, Yen CF, Shim DJ, et al. Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19). JAMA Cardiol. 2020:e201834. https://doi.org/10.1001/jamacardio.2020.1834 Web of Science®Google Scholar 3Bessière F, Roccia H, Delinière A, et al. Assessment of QT intervals in a case series of patients with coronavirus disease 2019 (COVID-19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit. JAMA Cardiol. 2020:e201787. https://doi.org/10.1001/jamacardio.2020.1787 Web of Science®Google Scholar 4Saleh M, Gabriels J, Chang D, et al. The effect of chloroquine, hydroxychloroquine and azithromycin on the corrected QT interval in patients with SARS-CoV-2 infection. Circ Arrhythm Electrophysiol, 2020. https://doi.org/10.1161/CIRCEP.120.008662 10.1161/CIRCEP.120.008662 Google Scholar 5Rosenberg ES, Dufort EM, Udo T, et al. Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York State. JAMA. 2020:e208630. https://doi.org/10.1001/jama.2020.8630 Google Scholar 6Drew BJ, Ackerman MJ, Funk M, et al. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Circulation. 2010; 121: 1047-60. 10.1161/CIRCULATIONAHA.109.192704 PubMedWeb of Science®Google Scholar Citing Literature Volume31, Issue8August 2020Pages 1904-1907 ReferencesRelatedInformation
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