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BIBTEX RIS

Investigation of Copaifera Genus as a New Source of Antimycobaterial Agents

2020; Future Science Ltd; Volume: 6; Issue: 7 Linguagem: Inglês

10.2144/fsoa-2020-0018

ISSN

2056-5623

Autores

J.A. Alves, Fariza Abrão, Thaís da Silva Moraes, Jaqueline Lopes Damasceno, Marcos F. Moraes, Rodrigo Cássio Sola Veneziani, Sérgio Ricardo Ambrósio, Jairo Kenupp Bastos, Mayker Lázaro Dantas Miranda, Carlos Henrique Gomes Martins,

Tópico(s)

Natural product bioactivities and synthesis

Resumo

Aim: This paper reports on the antimycobacterial activity of the oleoresins and extracts obtained from Copaifera spp. Materials & methods: The minimum inhibitory concentration (MIC) and fractional inhibitory concentration index techniques helped to evaluate the effect of these oleoresins and extracts against six strains of mycobacteria that cause tuberculosis. Results & conclusion: Among the assayed oleoresins and plant extracts, the Copaifera langsdorffii, Copaifera duckei, Copaifera reticulata and Copaifera trapezifolia oleoresins provided the lowest MIC values against some of the tested strains. The combination of Copaifera spp. samples with isoniazid did not evidence any synergistic action. Some Copaifera spp. oleoresins may represent a future source for the discovery of new antimycobacterial drugs due to their low MIC values.

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