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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

2020; American Association for the Advancement of Science; Volume: 12; Issue: 545 Linguagem: Inglês

10.1126/scitranslmed.aay1359

1946-6242

Mihalis S. Kariolis, Robert C. Wells, Jennifer A. Getz, Wanda Kwan, Cathal Mahon, Raymond K. Tong, Do Jin Kim, Ankita Srivastava, Catherine Bédard, Kirk R. Henne, Tina Giese, Victoria A. Assimon, Xiaocheng Chen, Yin Zhang, Hilda Solanoy, Katherine Jenkins, Pascal E. Sanchez, Lesley A. Kane, Takashi Miyamoto, Kylie S. Chew, Michelle E. Pizzo, Nicholas Liang, Meredith Calvert, Sarah L. DeVos, Sulochanadevi Baskaran, Sejal S. Hall, Zachary K. Sweeney, Robert G. Thorne, Ryan J. Watts, Mark S. Dennis, Adam P. Silverman, Y. Joy Yu Zuchero,

RNA Interference and Gene Delivery

Engineering human IgG1 Fc binding to a brain endothelial cell–enriched receptor allows enhanced brain exposure of biotherapeutics in multiple species.