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A Standard Set of Value-Based Patient-Centered Outcomes for Pancreatic Carcinoma: An International Delphi Survey

2020; Springer Science+Business Media; Volume: 28; Issue: 2 Linguagem: Inglês

10.1245/s10434-020-08679-0

1534-4681

Zineb Cherkaoui, Cristians González, Taiga Wakabayashi, Bastien Delattre, E. Léost, Sébastien Serra, J. Hûppertz, Francine Klein, M. Stephan, Jean-Michel Meyer, Alain Schaff, Elisa Martinis, Elena Bangoura, Sophie Kieffer, Sophie Blanès, Elham Haddad, Gabrielle De Guio, Emanuele Felli, Sophie Pernot, Jacques Marescaux, Didier Mutter, C. Lugiez, Patrick Pessaux, Paulo Cezar G AMARAL, Catherine T. Anthony, Raphael L. C. Araújo, Horacio J. Asbun, Susan Atkinson, Elena Bangoura, Marie-Pascale Bataille, Kimberly A. Bertens, Sophie Blanès, Javier Briceño, Carsten Palnæs Hansen, Maria Catalina Mursch, Clara Cesari-Loussouarn, Zineb Cherkaoui, Natalie G. Coburn, F. Colin, Claudius Conrad, Vincent Cordelier, Francis Crews, Vito De Blasi, Gabrielle Deguio, Bastien Delattre, Nicolas Demartines, Kristine Elberg Dengsø, Mark Doherty, Elena Fernández, David Fuks, A. Gil de Paz, Veronica Goldbarg, Cristians González, Elham Haddad, Julie Hallet, Nathalie Hausser, Rubén Hernández, Hugo Herrscher, Ryota Higuchi, Jens Hillingsø, Paul Hody, Pauline Horn, J. Hûppertz, Naoki Ikari, Wataru Izumo, Emilie Jacky, Shiva Jayaraman, Romane Jenner, Florence Le Jeune, Hironori Kaneko, Takaaki Kato, Suneil Khanna, Sophie Kieffer, Francine Klein, Jean Emmanuel Kurtz, Calvin Law, L. Lazarus, Myriam Lekeir, E. Léost, Bruno Lemos, Leonardo Pontual Lima, C. Lugiez, Bernadette Lux, Guilherme Henrique Machado, Jacques Marescaux, Guillaume Martel, Lysiane Marthey, Pablo Martí-Cruchaga, Elisa Martinis, Riccardo Memeo, Jean-Michel Meyer, Lise Munk Plum, César Velasco, Didier Mutter, Sulaiman Nanji, Amy O’connor, Akiko Omori, P. Osorio, Fabrizio Panaro, Fernando Pardo, Lucio Pereira, Pierre Perez, Sophie Pernot, Patrick Pessaux, Yolanda Quijano, Mariana Ramallo, Nicolas Régenet, Alexandre Resende, Fernando Rotellar, António Sá Cunha, Rodrigo Sánchez Clariá, Daniel Santana, Rodolfo M.M. Santana, Alain Schaff, Lilian Schwarz, Maja Segedi, Sébastien Serra, Pablo E. Serrano, Masahiro Shiihara, Olivier Soubrane, M. Stephan, Nobuhiro Takeshita, Orlando Jorge Martins Torres, Melanie Tsang, Olivıer Turrini, Shuichiro Uemura, E. G. Del Valle, Anna Van Osch, Emilio Vicente, Annie Vincent, Go Wakabayashi, Taiga Wakabayashi, Helmut Weiss, Masakazu Yamamoto, Shingo Yamashita, Takehisa Yazawa, Thomas Zacharias,

Colorectal Cancer Screening and Detection

Global health systems are shifting toward value-based health care to improve patient outcomes in the face of rising health care costs. The challenge is to identify standardized outcome measurements that allow optimal quality-of-care monitoring and comparison to optimize medical practices and patient pathways. A common outcomes definition is required, including medical results (Clinical Reported Outcomes Measurements [CROMs]) and quality-of-life components that matter most to patients (Patient-Reported Outcomes Measurements [PROMs]), which are particularly important for severe pathologies with short life expectancy such as pancreatic cancer. This study aimed to create standardized metrics that could be used for outcomes analysis of pancreatic cancer care. A multidisciplinary working group (WG) was assembled. A systematic review was performed to collect the most used outcomes in clinical studies of pancreatic cancers. The study reviewed 570 studies published in the last 10 years. From these studies, 3370 outcomes, including CROMs, and PROMs, were listed and prioritized. The WG reached a consensus on key outcomes, proposed groupings for CROMs and PROMs, identified existing questionnaires that could be used for PROMs collection, and set the timeline for data collection. To refine and validate the final outcomes set, an international external committee completed a Delphi process (two rounds for both CROMS and PROMs). After the systematic literature review, the WG selected 102 outcomes (92 CROMs and 10 PROMs) for submission to the international Delphi vote committee. The committee retrained 89 outcomes (78 CROMs and 11 PROMs). For the PROMs, the WG and the international external committee chose a validated questionnaire, the Functional Assessment of Cancer Therapy-Hepatobiliary, which covers all of the 11 selected PROMs. A standardized set of outcome measures that need to be validated through international health outcome comparisons and quality-of-care assessments was built. Pilot projects are underway to test and optimize the approach in real-life conditions.