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Revisão Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Covid-19: the renin–angiotensin system imbalance hypothesis

2020; Portland Press; Volume: 134; Issue: 11 Linguagem: Inglês

10.1042/cs20200492

ISSN

1470-8736

Autores

Katharina Lanza, Lucas Giandoni Perez, Larissa Braga Costa, Thiago Macedo e Cordeiro, Vitria A. Palmeira, Victor Teatini Ribeiro, Ana Cristina Simões e Silva,

Tópico(s)

Long-Term Effects of COVID-19

Resumo

The emergency of SARS-CoV-2 in China started a novel challenge to the scientific community. As the virus turns pandemic, scientists try to map the cellular mechanisms and pathways of SARS-CoV-2 related to the pathogenesis of Coronavirus Disease 2019 (Covid-19). After transmembrane angiotensin-converting enzyme 2 (ACE2) has been found to be SARS-CoV-2 receptor, we hypothesized an immune-hematological mechanism for Covid-19 based on renin-angiotensin system (RAS) imbalance to explain clinical, laboratory and imaging findings on disease course. We believe that exaggerated activation of ACE/Angiotensin II (Ang II)/Angiotensin Type 1 (AT1) receptor RAS axis in line with reduction of ACE2/Angiotensin-(1-7)/Mas receptor may exert a pivotal role in the pathogenesis of Covid-19. In this perspective, we discuss potential mechanisms and evidence on this hypothesis.

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