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Night shift work and immune response to the meningococcal conjugate vaccine in healthy workers: a proof of concept study

2020; Elsevier BV; Volume: 75; Linguagem: Inglês

10.1016/j.sleep.2020.05.032

1878-5506

Francieli S. Ruiz, Daniela Santoro Rosa, Ioná Zalcman Zimberg, Marcus Vinicius Lúcio dos Santos Quaresma, Jethe O.F. Nunes, Juliana de Souza Apostólico, Lily Yin Weckx, Alessandra R. Souza, Fernanda Veruska Narciso, Silvio A. Fernandes‐Junior, Bruno da Silva Brandão Gonçalves, Simon Folkard, Lia Bittencourt, Sérgio Tufik, Marco Túlio de Mello,

Sleep and related disorders

It is well-established that sleep regulates immune functions. Immunological functions are dependent on circadian rhythms and regular sleep as both have an impact on the magnitude of immune responses following antigenic challenge (eg, in vaccination). Here we investigated whether nocturnal shift work can influence post-vaccination response. Thirty-four healthy workers (23 females) working either nocturnal or diurnal shifts (17 in each group) received the meningococcal C meningitis vaccine. Sleep was recorded polysomnographically (PSG) and with actigraphy. Humoral and cellular responses were assessed after vaccination. Night workers showed decreased N3 stage and REM sleep duration, increased inflammatory mediators (TNF-α and IL-6 levels), and a weak specific humoral response to vaccination associated with reduced CD4 T lymphocytes, reduced plasmacytoid dendritic cells, reduced prolactin levels, increased TReg and increased IL-10 levels. In addition, the decrease in total sleep time and circadian rhythm alterations were associated with a reduced humoral response post-vaccination. Our findings provide novel evidence concerning immune alterations of shift work on workers' health based on real-life circumstances. In association with circadian components, sufficient sleep time and rhythm synchronization were important for the development of the Ag-specific immune response, suggesting that the humoral response to vaccination may be impaired in individuals with chronic sleep restriction and circadian misalignment.