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Reduced graphene oxide, but not carbon nanotubes, slows murine melanoma after thermal ablation using LED light in B16F10 lineage cells

2020; Elsevier BV; Volume: 28; Linguagem: Inglês

10.1016/j.nano.2020.102231

1549-9642

Rosemeire F.O. de Paula, Ingrid Alves Rosa, Ingrid F.M. Gafanhão, José Luís Fachi, Anna Maria G. Melero, Aléxia O. Roque, Vinícius Boldrini, Luiz Alberto Bandeira Ferreira, Silvia Pierre Irazusta, Helder José Ceragioli, Elaine C. Oliveira,

Graphene and Nanomaterials Applications

Photodynamic therapy is a minimally invasive health technology used to treat cancer and other non-malignant diseases, as well as inactivation of viruses, bacteria and fungi. In this work, we sought to combine the phototherapy technique using low intensity LED (660 nm) to induce ablation in melanoma tumor in mice treated with nanoparticles. In vitro and in vivo studies were conducted, and our results demonstrated that multi-walled carbon nanotubes (MWCNTs) do not destroy tumor cells in vivo, but stimulate the inflammatory process and angiogenesis. Reduced graphene oxide (rGO), has been shown to play a protective role associated with the LED ablation, inducing necrosis, stimulation of immune response by lymphoproliferation, and decreased tumor mass in vivo. We consider that LED alone can be very effective in controlling the growth of melanoma tumors and its association with rGO is potentiated.