Portal de Periódicos da CAPES

AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies

2020; American Physical Society; Volume: 319; Issue: 1 Linguagem: Inglês

10.1152/ajpheart.00644.2019

1522-1539

Ramón A. Lorca, Christopher J. Matarazzo, Elise S. Bales, Julie A. Houck, David J. Orlicky, Anna G. Euser, Colleen G. Julian, Lorna G. Moore,

Gestational Diabetes Research and Management

High-altitude (>2,500 m) residence increases the incidence of intrauterine growth restriction (IUGR) due, in part, to reduced uterine artery blood flow and impaired myometrial artery (MA) vasodilator response. A role for the AMP-activated protein kinase (AMPK) pathway in protecting against hypoxia-associated IUGR is suggested by genomic and transcriptomic studies in humans and functional studies in mice. AMPK is a hypoxia-sensitive metabolic sensor with vasodilatory properties. Here we hypothesized that AMPK-dependent vasodilation was increased in MAs from high versus low-altitude ( 2,500 m) with appropriate for gestational age pregnancies but not in IUGR pregnancies at any altitude.