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Pneumomediastinum Related to Covid-19 Pneumonia

2020; Elsevier BV; Volume: 360; Issue: 6 Linguagem: Inglês

10.1016/j.amjms.2020.06.003

1538-2990

Nicola Romano, Aldo Fischetti, Enrico Francesco Melani,

Streptococcal Infections and Treatments

In March 2020, during the pandemic scenario of the new coronavirus, named Severe Acute Respiratory Syndrome Coronavirus 2 related to the novel viral pneumonia consequently named Covid-19 (Coronavirus Disease 2019), several chest computed tomography (CT) scans were performed in suspected cases to evaluate pulmonary involvement and stage the disease. At the same time, scientific papers have illustrated the most common radiological features of the Covid-19 pneumonia: multifocal bilateral peripheral ground glass areas and subsegmental patchy consolidations with subpleural location and predominant involvement of lower lung lobes and posterior segments. In this context, among the different patterns and findings described, the presence of pneumomediastinum was rarely reported in literature, 1 Zhou C Gao C Xie Y et al. COVID-19 with spontaneous pneumomediastinum. Lancet Infect Dis. 2020; 20: 510 Abstract Full Text Full Text PDF PubMed Scopus (178) Google Scholar , 2 Sun R Liu H Wang X Mediastinal emphysema, giant bulla, and pneumothorax developed during the course of Covid-19 pneumonia. Korean J Radiol. 2020; 21: 541‐544 Crossref PubMed Scopus (212) Google Scholar , 3 Kolani S Nawfal H Haloua M et al. Spontaneous pneumomediastinum occurring in the SARS-COV-2 infection. IDCases. 2020; 21: e00806 Crossref PubMed Scopus (57) Google Scholar and rarely considered in scientific debates. We herein report two cases of pneumomediastinum related to Covid-19 pneumonia, in patients who underwent chest-CT scan in our Hospital. The first patient was a 30-year-old male, who complained of fever (37.6°) and dyspnea with wheezing sounds at auscultation. Laboratory tests showed elevated leukocytes (13,180 cells per μL) with 13,4% of lymphocytes; C-reactive protein was mildly elevated (3.26 mg/L). Unenhanced chest CT-scan revealed the presence of some small ground-glass opacities bilaterally, in particular in para-cardiac regions of superior and inferior lobes, findings compatible with Covid-19 pneumonia. Surprisingly, an amount of free air bubbles was present in the superficial cervical soft tissue (around sternocleidomastoid muscles and thyroid gland) and descending into the mediastinal cavity (around trachea, esophagus and great vessels; Figure A, B). The second patient underwent a follow-up CT 2 weeks later that showed resolution of the pneumomediastinum. The second patient was a 65-year-old male, presented to emergency complaining of severe dyspnea, with associated low oxygen saturation and fever. Complete blood count showed elevated leukocytes (23,710 cells per μL) with only 6.6% of lymphocytes; elevation of C-reactive protein (4.01 mg/dL), lactate dehydrogenase (627 μ/L), glutamic-oxaloacetic transaminase (57 μ/L) and glutamic-pyruvic transaminase (154 μ/L) was also present. Unenhanced chest CT-scan (partially influenced by respiratory motion artifacts) demonstrated bilateral areas of ground-glass opacity and consolidations diffused bilaterally in pulmonary lobes, features compatible with the suspicion of Covid-19 pneumonia; also in this case, an abundant pneumomediastinum was present, associated with cervical soft-tissue emphysema (Figure C-E). Nasopharyngeal swab test for Covid-19 confirmed infection and the follow-up CT done 2 weeks later demonstrated the complete resolution of pneumomediastinum and soft tissue emphysema. As known, a spontaneous pneumomediastinum may be caused by a pressure gradient between the alveoli and pulmonary interstitium leading to alveolar breakdown as described by Macklin. 4 Macia I Moya J Ramos R et al. Spontaneous pneumomediastinum: 41 cases. Eur J Cardiothorac Surg. 2007; 31: 1110‐1114 Crossref Scopus (232) Google Scholar In cases of infection by SARS-CoV, pneumomediastinum may be related to damage and rupture of alveolar membrane caused by the virus. 3 Kolani S Nawfal H Haloua M et al. Spontaneous pneumomediastinum occurring in the SARS-COV-2 infection. IDCases. 2020; 21: e00806 Crossref PubMed Scopus (57) Google Scholar ,5 Gralinski LE Baric RS. Molecular pathology of emerging coronavirus infections. J Pathol. 2015; 235: 185-195 Crossref PubMed Scopus (242) Google Scholar Although pneumomediastinum is usually considered a self-limiting condition, with an unknown precise pathological mechanism, we wanted to describe this possible complication of Covid-19 pneumonia, that may be considered a potential indicator of worsening disease. 1 Zhou C Gao C Xie Y et al. COVID-19 with spontaneous pneumomediastinum. Lancet Infect Dis. 2020; 20: 510 Abstract Full Text Full Text PDF PubMed Scopus (178) Google Scholar