A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice
2020; Elsevier BV; Volume: 57; Linguagem: Inglês
10.1016/j.ebiom.2020.102825
ISSN2352-3964
AutoresYuanyuan Kuang, Veronica Zorzi, Damiano Buratto, Gaia Ziraldo, Flavia Mazzarda, Chiara Peres, Chiara Nardin, Anna Maria Salvatore, Francesco Chiani, Ferdinando Scavizzi, Marcello Raspa, Min Qiang, Youjun Chu, Xiaojie Shi, Yu Li, Lili Liu, Yaru Shi, Francesco Zonta, Guang Yang, Richard A. Lerner, Fabio Mammano,
Tópico(s)Erythrocyte Function and Pathophysiology
ResumoNumerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations generate abnormally active Cx hemichannels, referred to also as "leaky" hemichannels. The goal of this study was to assay the in vivo efficacy of a potent antagonist antibody targeting Cx hemichannels.
Referência(s)