Portal de Periódicos da CAPES

Revisão Produção Nacional Revisado por pares

BIBTEX RIS

A Biobank of Stem Cells of Human Exfoliated Deciduous Teeth: Overview of Applications and Developments in Brazil

2020; Karger Publishers; Volume: 209; Issue: 1 Linguagem: Inglês

10.1159/000506677

1422-6405

Bianca Rapini Zalaf, Mayara Bringel, Paula Karine Jorge, Bárbara de Oliveira, Kim Tanabe Moura Leite, Carlos Ferreira Santos, Rodrigo Cardoso de Oliveira, Daniela Ríos, Thiago Cruvinel, Natalino Lourenço Neto, Thaís Marchini de Oliveira, María Aparecida de Andrade Moreira Machado,

Biomedical Ethics and Regulation

A biobank is an organized collection of biological human material and its associated information stored for research according to regulations under institutional responsibility, without commercial purposes, being a mandatory and strategical activity for research, regenerative medicine, and innovation. Stem cells have largely been employed in research and frequently stored in biobanks, which have been used as an essential source of biological materials. Stem cells of human exfoliated deciduous teeth (SHED) are stem cells which have a high multipotency and can be easily obtained. Besides, this extremely accessible tissue has advantages with respect to storage, as the SHED obtained in childhood can be used in later life, which implies the necessity for the creation and regulation of biobanks. The proper planning for the creation of a biobank includes knowledge of the material types to be stored, requirements regarding handling and storage conditions, storage time, and room for the number of samples. Thus, this study aimed to establish an overview of the development of a SHED biobank. Ethical and legal standardization, current applications, specific orientations, and challenges for the implementation of a SHED biobank were discussed. Through this overview, we hope to encourage further studies to use SHED biobanks.