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NOVEL antioxidant and oxidant biomarkers related to sarcopenia in COPD

2020; Elsevier BV; Volume: 50; Issue: 1 Linguagem: Inglês

10.1016/j.hrtlng.2020.06.001

1527-3288

Walter Sepúlveda‐Loyola, Larissa Araújo de Castro, Andressa Keiko Matsumoto, Carlos Augusto Camillo, Décio Sabbatini Barbosa, Carrie Chueiri Ramos Galvan, Vanessa Suziane Probst,

Cardiovascular and exercise physiology

Background The relation between oxidative stress (OS) and sarcopenia in COPD remains unknown. Objective To analyze OS levels and its association with sarcopenia in COPD. Methods Thirty-nine individuals with COPD (69±7years; 41%female) and thirty-five for the control group (69±7years; 43%female) were included. Advanced oxidation protein products (AOPP), paraoxonase-1 (PON1), superoxide dismutase activity (SOD), catalase dismutase activity (CAT), sulfhydryl group (SH), nitric oxide metabolites (NOX), total radical trapping antioxidant parameter (TRAP) were analysed. OS markers were correlated with handgrip and quadriceps strength, gait speed, skeletal muscle mass index, fat-free mass index, maximum inspiratory and expiratory pressure. European criteria were used to identify sarcopenia. Results In COPD, antioxidant capacity was correlated with muscle mass and strength (r from 0.5 to 0.64) P<0.05 for all. TRAP≤ 850 μM/trolox and AOPP≤65 μM/l were associated with sarcopenia (OR:8.3; 95% CI: 1.4–49.6 and OR:14; 95%CI: 2.2–87.1, respectively; P<0.05 for both). Conclusion OS is associated with sarcopenia in COPD.