Portal de Periódicos da CAPES

Molecular epidemiology of predominant and emerging Clostridioides difficile ribotypes

2020; Elsevier BV; Volume: 175; Linguagem: Inglês

10.1016/j.mimet.2020.105974

1872-8359

Adrián Martínez-Meléndez, Rayo Morfín‐Otero, Licet Villarreal-Treviño, Simon D. Baines, Adrián Camacho-Ortíz, Elvira Garza‐González,

Microscopic Colitis

There has been an increase in the incidence and severity of Clostridioides difficile infection (CDI) worldwide, and strategies to control, monitor, and diminish the associated morbidity and mortality have been developed. Several typing methods have been used for typing of isolates and studying the epidemiology of CDI; serotyping was the first typing method, but then was replaced by pulsed-field gel electrophoresis (PFGE). PCR ribotyping is now the gold standard method; however, multi locus sequence typing (MLST) schemes have been developed. New sequencing technologies have allowed comparing whole bacterial genomes to address genetic relatedness with a high level of resolution and discriminatory power to distinguish between closely related strains. Here, we review the most frequent C. difficile ribotypes reported worldwide, with a focus on their epidemiology and genetic characteristics.