Produção Nacional
Revisado por pares
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
2020; Nature Portfolio; Volume: 11; Issue: 1 Linguagem: Inglês
10.1038/s41467-020-16765-w
ISSN2041-1723
AutoresAndrea Strakova, Thomas J. Nicholls, Adrian Baez‐Ortega, Máire Ní Leathlobhair, Alex Sampson, Katherine Hughes, Isobelle A. G. Bolton, Kevin Gori, Jinhong Wang, Ilona Airikkala‐Otter, Janice L. Allen, Karen M. Allum, Clara L. Arnold, Leontine Bansse-Issa, Thinlay N. Bhutia, Jocelyn Bisson, Kelli Blank, Cristóbal Briceño, Artemio Castillo Domracheva, Anne M. Corrigan, Hugh R. Cran, Jane T. Crawford, Stephen M Cutter, Eric Davis, Karina Ferreira de Castro, Andrígo Barboza De Nardi, Anna P. de Vos, Laura Keenan, Edward M. Donelan, Adela R. Espinoza Huerta, Ibikunle A. Faramade, Mohammed Fazil, Eleni Fotopoulou, Skye N. Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Pagona G. Gοuletsοu, Rodrigo F. Häfelin Manrique, Joaquim Henriques, Rodrigo dos Santos Horta, Natalia A. Ignatenko, Yaghouba Kane, Cathy King, Debbie Koenig, A. Krupa, Steven J. Kruzeniski, Marta Lanza‐Perea, Mihran Lazyan, Adriana M. Lopez Quintana, Thibault Losfelt, Gabriele Marino, José Simón Martínez-Castañeda, Mayra Fernanda Martínez-López, Bedan M. Masuruli, Michael J. Meyer, Edward J. Migneco, Berna Nakanwagi, Karter B. Neal, Winifred Neunzig, Sally J. Nixon, Antonio Ortega‐Pacheco, Francisco Pedraza, Maria C. Peleteiro, Katherine Polak, Ruth J. Pye, Juan C. Ramirez-Ante, John F. Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K. Schmeling, Olga Shamanova, Alan G. Sherlock, Audrey E. Steenland-Smit, Alla Svitich, Lester J. Tapia Martínez, Ismail Thoya Ngoka, Cristian G. Torres, Elizabeth M. Tudor, Mirjam G. van der Wel, Bogdan Alexandru Vițălaru, Sevil Atalay Vural, Oliver Walkinton, Alvaro Wehrle-Martinez, Sophie A. E. Widdowson, Irina Zvarich, Patrick F. Chinnery, Maria Falkenberg, Claes M. Gustafsson, Elizabeth P. Murchison,
Tópico(s)Human-Animal Interaction Studies
ResumoAbstract Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby ‘selfish’ positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.
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