Ray tracing models for estimating light collection properties of microstructured tapered optical fibers for optical neural interfaces
2020; Optica Publishing Group; Volume: 45; Issue: 14 Linguagem: Inglês
10.1364/ol.397022
ISSN1539-4794
AutoresEmanuela Maglie, Marco Pisanello, Filippo Pisano, Antonio Balena, Marco Bianco, Barbara Spagnolo, Leonardo Sileo, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello,
Tópico(s)Optical Coherence Tomography Applications
ResumoTapered optical fibers (TFs) were recently employed for depth-resolved monitoring of functional fluorescence in subcortical brain structures, enabling light collection from groups of a few cells through small optical windows located on the taper edge [Pisano et al ., Nat. Methods 16 , 1185 ( 2019 ) 1548-7091 10.1038/s41592-019-0581-x ]. Here we present a numerical model to estimate light collection properties of microstructured TFs implanted in scattering brain tissue. Ray tracing coupled with the Henyey–Greenstein scattering model enables the estimation of both light collection and fluorescence excitation fields in three dimensions, whose combination is employed to retrieve the volume of tissue probed by the device.
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