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Oral resveratrol supplementation improves Metabolic Syndrome features in obese patients submitted to a lifestyle-changing program

2020; Elsevier BV; Volume: 256; Linguagem: Inglês

10.1016/j.lfs.2020.117962

1879-0631

Gislaine Cândida Batista-Jorge, Antônio Sérgio Barcala-Jorge, Marise Fagundes Silveira, Deborah F. Lelis, João Marcus Oliveira Andrade, Alfredo Maurício Batista de Paula, André Luiz Sena Guimarães, Sérgio Henrique Sousa Santos,

Adipokines, Inflammation, and Metabolic Diseases

The aim of the present study was to evaluate the oral resveratrol effects associated with diet and physical training changes on anthropometric and biochemical parameters. 25 individuals aged from 30 to 60 years old; with Body Mass Index (BMI) ≥ 30 kg/m2 were included in the study. Following the primary evaluation (anthropometric and clinical), the patients were randomly divided into 2 groups: (1) Placebo: Physical activity program + Diet + Placebo; (2) Resveratrol: Physical activity program + Diet + Resveratrol (RVS) (250 mg/day) for three months. Anthropometric and biochemical parameters were evaluated at baseline and after the treatment period. The main findings showed that the resveratrol supplementation improved total cholesterol (TC), High-density Lipoprotein cholesterol (HDL-c), Very-low density Lipoprotein cholesterol (VLDL-c), urea, creatinine and albumin serum levels. These findings indicate that this polyphenol may be an option to potentiate the beneficial effects induced by dietary and physical activity programs in the Metabolic Syndrome (MetS) treatment.