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Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

2020; eLife Sciences Publications Ltd; Volume: 9; Linguagem: Inglês

10.7554/elife.59391

2050-084X

Nick K Jones, Lucy Rivett, Dominic Sparkes, Stephen R. Forrest, Sushmita Sridhar, Jamie Young, Joana Pereira-Dias, Claire Cormie, Harmeet K. Gill, Nicola Reynolds, Michelle Wantoch, Matthew Routledge, Ben Warne, Jack Levy, William David Córdova Jiménez, Fathima Nisha Begum Samad, Chris McNicholas, Mark Ferris, Jane Gray, Michael B. Gill, Stephen Baker, John R. Bradley, Gordon Dougan, Ian Goodfellow, Ravi Gupta, Paul J. Lehner, Paul Lyons, Nicholas J. Matheson, Kenneth G. C. Smith, M. Estée Török, Mark Toshner, Michael P. Weekes, Nick K Jones, Lucy Rivett, Matthew Routledge, Dominic Sparkes, Ben Warne, Claire Cormie, Stephen R. Forrest, Harmeet K. Gill, Iain Kean, Joana Pereira-Dias, Nicola Reynolds, Sushmita Sridhar, Michelle Wantoch, Jamie Young, Sarah Caddy, Laura Caller, Theresa Feltwell, Grant Hall, William L. Hamilton, Myra Hosmillo, Charlotte J. Houldcroft, Aminu S. Jahun, Fahad Khokhar, Luke W. Meredith, Anna Yakovleva, Helen Butcher, Daniela Caputo, Debra Clapham-Riley, Helen Dolling, Anita Furlong, Barbara Graves, Emma Le Gresley, Nathalie Kingston, Sofia Papadia, Hannah Stark, Kathleen Stirrups, Jennifer Webster, Joanna Calder, Julie R. Harris, Sarah H. Hewitt, Jane Kennet, Anne Meadows, Rebecca Rastall, Criona O Brien, Jo Price, Cherry Publico, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Michael B. Gill, Jane Gray, Greg Hannon, Karen Brookes, Laura Canna, Isabel Cf da Cruz, Katie Dempsey, Anne Elmer, Naidine Escoffery, Stewart Fuller, Heather Jones, Carla M. S. Ribeiro, Caroline Saunders, Angela Wright, Rutendo Nyagumbo, Anne M. Roberts, Ashlea Bucke, Simone Hargreaves, Danielle Johnson, Aileen Narcorda, Debbie Read, Christian Sparke, Lucy Worboys, Kirsty Lagadu, Lenette Mactavous, T Gould, Tim Raine, Ashley Shaw, Claire Mather, Nicola Ramenatte, Anne-Laure Vallier, Mary Kasanicki, Penelope-Jane Eames, Chris McNicholas, Lisa Thake, Neil Bartholomew, Nicholas M. Brown, Martin D. Curran, Surendra Parmar, Hongyi Zhang, Ailsa Bowring, Mark Ferris, Geraldine Martell, Natalie Quinnell, Giles Wright, Jo Wright, Helen Murphy, Benjamin J. Dunmore, Ekaterina Legchenko, Stefan Ting Graf, Christopher Huang, Josh Hodgson, Kelvin Hunter, Jennifer Martin, Federica Mescia, Ciara O’Donnell, Linda Pointon, Joy Shih, Rachel Sutcliffe, Tobias Tilly, Zhen Tong, Carmen Treacy, Jennifer Wood, Laura Bergamaschi, Ariana Betancourt, Georgie Bowyer, Aloka De, Maddie Epping, Andrew Hinch, Oisín Huhn, Isobel Jarvis, Daniel Lewis, Joe Marsden, Simon McCallum, Francescsa Nice, Ommar Omarjee, Marianne Perera, Nika Romashova, Mateusz Strezlecki, Natalia Savoinykh Yarkoni, Lori W. Turner, Barrie Bailey, Afzal Chaudhry, Rachel Doughton, Christopher T. Workman, Caroline Trotter, William David, Cordova Jiménez, Jack Levy, Fatima Samad, Martin D. Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, John R. Bradley, Gregory J. Hannon, Ian Goodfellow, Gordon Dougan, Kenneth G. C. Smith, Paul J. Lehner, Giles Wright, Nicholas J. Matheson, Stephen Baker, Michael P. Weekes,

COVID-19 Clinical Research Studies

Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive for SARS-CoV-2 (Rivett et al., 2020). Here, we show that the proportion of both asymptomatic and symptomatic HCWs testing positive for SARS-CoV-2 rapidly declined to near-zero between 25th April and 24th May 2020, corresponding to a decline in patient admissions with COVID-19 during the ongoing UK 'lockdown'. These data demonstrate how infection prevention and control measures including staff testing may help prevent hospitals from becoming independent 'hubs' of SARS-CoV-2 transmission, and illustrate how, with appropriate precautions, organizations in other sectors may be able to resume on-site work safely.