Radical addition of tetrahydrofuran to imines assisted by tert-butyl hydroperoxide
2020; Elsevier BV; Volume: 61; Issue: 30 Linguagem: Inglês
10.1016/j.tetlet.2020.152150
ISSN1873-3581
AutoresVera A. Vil’, Sergei S. Grishin, Е. П. Баберкина, Vera A. Kostyagina, А. E. Kovalenko, Alexander O. Terent’ev,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoThe TBHP-promoted selective radical addition of tetrahydrofuran to imines resulting in β-amino ethers has been developed. The presented radical method of β-amino ether synthesis is based on initiation by available TBHP and does not require metal catalysis or light irradiation. Variety of β-amino ethers are formed in good to excellent yields, despite the possible side oxidation pathways: ether α-oxidation, the transformation of starting imines into amides, target β-amino ethers dehydrogenation.
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