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Antioxidant and antimicrobial activity of red propolis embedded mesoporous silica nanoparticles

2020; Taylor & Francis; Volume: 46; Issue: 7 Linguagem: Inglês

10.1080/03639045.2020.1782423

1520-5762

Laís F. Azevedo de M. Oliveira, Lais Vanessa de Azevedo Teles da Silva, Ticiano Gomes do Nascimento, Lara Mendes de Almeida, Rodrigo José Nunes Calumby, Ábner Magalhães Nunes, Leonardo M.T.M. Oliveira, E. J. S. Fonseca,

Microencapsulation and Drying Processes

This work brings the promise of MCM-41 mesoporous silica as a vehicle for red propolis for the development of controlled release drugs and delivery to a specific target site. The synthesis of MCM-41 by the sol–gel method with a pore size of approximately 3.6 nm and the incorporation of red propolis extract by the physical adsorption method in ethanolic medium were easily accomplished with around 15% encapsulation. MCM-41 and MCM-41 with red propolis (MCM-41/Pr) were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermal analysis, N2 adsorption–desorption, scanning electron microscopy, and an ultra-high-performance liquid chromatography–diode array detection (UPLC-DAD). In vitro release of encapsulated red propolis was analyzed in phosphate buffer at pH 7.2, 7.4, and 7.6. An in vitro test for MCM-41/Pr antioxidant activity was performed using 2,2-diphenyl-1-picrylhydrazyl as well as analysis of antibacterial activity against Staphylococcus aureus by the well diffusion method. UPLC-DAD analysis showed that the integrity of the red propolis constituents was maintained after the embed process, and the antioxidant and antibacterial activities were preserved.