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Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury

2020; National Academy of Sciences; Volume: 117; Issue: 27 Linguagem: Inglês

10.1073/pnas.2005477117

1091-6490

Yuhei Kirita, Hao Wu, Kohei Uchimura, Parker C. Wilson, Benjamin D. Humphreys,

3D Printing in Biomedical Research

Significance Single nucleus RNA sequencing revealed gene expression changes during repair after acute kidney injury. We describe a small population of proximal tubule cells that fail to repair (FR-PTCs). Since this subpopulation expresses abundant proinflammatory and profibrotic genes, it may represent a new therapeutic target to improve repair and reduce fibrosis after AKI.