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ctDNA monitoring using patient-specific sequencing and integration of variant reads

2020; American Association for the Advancement of Science; Volume: 12; Issue: 548 Linguagem: Inglês

10.1126/scitranslmed.aaz8084

1946-6242

Jonathan C. M. Wan, Katrin Heider, Davina Gale, Suzanne Murphy, Eyal Fisher, Florent Moulière, Andrea Ruiz-Valdepeñas, Ángela Santonja, James Morris, Dineika Chandrananda, Andrea Marshall, Andrew B. Gill, Pui Ying Chan, Emily Barker, Gemma Young, Wendy N. Cooper, Irena Hudecova, Francesco Marass, Richard Mair, Kevin M. Brindle, Grant D. Stewart, Jean Abraham, Carlos Caldas, Doris M. Rassl, Robert C. Rintoul, Constantine Alifrangis, Mark R. Middleton, Ferdia A. Gallagher, Christine Parkinson, Amer Durrani, Ultan McDermott, Christopher G. Smith, Charles Massie, Pippa Corrie, Nitzan Rosenfeld,

Genomics and Phylogenetic Studies

Integration of variant reads across patient-specific mutation loci enables sensitive ctDNA quantification in plasma cell-free DNA sequencing data.