Produção Nacional
Revisado por pares
Butaphosphan Effects on Glucose Metabolism Involve Insulin Signaling and Depends on Nutritional Plan
2020; Multidisciplinary Digital Publishing Institute; Volume: 12; Issue: 6 Linguagem: Inglês
10.3390/nu12061856
ISSN2072-6643
AutoresM Weiller, Joao Alveiro Alvarado Rincón, Carolina Bespalhok Jacometo, Carlos Castilho Barros, Izabel Cristina Custódio de Souza, Lucas Teixeira Hax, Thaís Casarin da Silva, Patrícia Mattei, Antônio Amaral Barbosa, Josiane de Oliveira Feijó, Rubens Alves Pereira, Cássio Cassal Brauner, Viviane Röhrig Rabassa, Francisco Augusto Burkert Del Pino, Márcio Nunes Corrêa,
Tópico(s)Muscle Physiology and Disorders
ResumoButaphosphan is an organic phosphorus compound used in several species for the prevention of rapid catabolic states, however, the mechanism of action remains unclear. This study aimed at determining the effects of butaphosphan on energy metabolism of mice receiving a normal or hypercaloric diet (HCD) and submitted or not to food restriction. Two experiments were conducted: (1) during nine weeks, animals were fed with HCD (n = 28) ad libitum, and at the 10th week, were submitted to food restriction and received butaphosphan (n = 14) or saline injections (n = 14) (twice a day, for seven days) and; (2) during nine weeks, animals were fed with a control diet (n = 14) or HCD (n = 14) ad libitum, and at the 10th week, all animals were submitted to food restriction and received butaphosphan or saline injections (twice a day, for seven days). In food restriction, butaphosphan preserved epididymal white adipose tissue (WAT) mass, increased glucose, NEFA, and the HOMA index. In mice fed HCD and submitted to food restriction, the butaphosphan preserved epididymal WAT mass. Control diet influences on PI3K, GCK, and Irs1 mRNA expression. In conclusion, butaphosphan increased blood glucose and reduced fat mobilization in overweight mice submitted to caloric restriction, and these effects are influenced by diet.
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