Polymer Discs with High Interfacial Adhesion Fabricated from Hot-Pressing of Microspheres
2020; American Chemical Society; Volume: 2; Issue: 8 Linguagem: Inglês
10.1021/acsapm.0c00465
ISSN2637-6105
AutoresHong Zhang, Waranyou Tuntanatewin, Kenichi Ishikura, Daiki Sogabe, Kodai Sugawara, Akira Tokui, Atsushi Nakagawa, Yosuke Okamura,
Tópico(s)3D Printing in Biomedical Research
ResumoOwing to the large contact surface area in geometry, disc-shaped polymer particles and their fascinating properties compared to those of spherical particles have received increasing attention. Although a variety of methods have been developed, fabricating polymer discs in a facile and versatile manner remains a challenge. In this study, we propose a method to fabricate polymer discs by a hot-press process combined with a sacrificial matrix technique, where only aqueous solutions and suspensions are employed. By embedding polymer microspheres in alginate gel, space between the microspheres is created, and thus, the microspheres can be deformed into individual discs after hot-pressing near the Tg of the polymer. As case studies, polystyrene, poly(L-lactic acid), and poly(D,L-lactide-co-glycolide) microspheres with a wide range of sizes were processed into polymer discs. The choice of sacrificial matrix and the optimal condition for hot-pressing are also discussed. Moreover, the high interfacial adhesion of the prepared discs was verified, including the adhesiveness of polymer discs to the surface of a cover glass under airflow, as well as the enhancement of aggregation for bovine serum albumin-coated polymer discs in the presence of glutaraldehyde. We suggest that the enhanced adhesiveness of polymer discs can improve their performances in both particle-based targeted drug delivery and latex turbidimetric immunoassay.
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