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Steep Rebound of Chloroquine-Sensitive Plasmodium falciparum in Zimbabwe

2020; Oxford University Press; Volume: 223; Issue: 2 Linguagem: Inglês

10.1093/infdis/jiaa368

1537-6613

Sungano Mharakurwa, Zvifadzo Matsena Zingoni, Nobert Mudare, Charmaine Matimba, Tanatswa Xuxa Gara, Aramu Makuwaza, Gladys Maponga, Shungu Munyati, Lovemore Gwanzura, Susan Mutambu, Peter Mason, Tamaki Kobayashi, Nicholas Midzi, William J. Moss, Matthew M. Ippolito,

Travel-related health issues

Removal of chloroquine from national malaria formularies can lead to the reversion of resistant Plasmodium falciparum to wild-type. We report a steep decline in chloroquine-resistant P falciparum within 10 years of national discontinuation of chloroquine monotherapy in Zimbabwe. Drug resistance surveillance is a vital component of malaria control programs, and the experience with chloroquine in Zimbabwe and elsewhere in sub-Saharan Africa is illustrative of the potentially rapid and dramatic impact of drug policy on antimalarial resistance.