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Hybrid valve-in-valve mitral valve replacement

2020; Elsevier BV; Volume: 3; Linguagem: Inglês

10.1016/j.xjtc.2020.05.032

2666-2507

Morgan Harloff, Andrew R. Papoy, Ayaz Aghayev, Tsuyoshi Kaneko,

Cardiovascular Function and Risk Factors

Central MessageHybrid valve-in-valve mitral valve replacement (MVR) may add another option to address the problem of left ventricular outflow tract obstruction in high-risk patients for whom repeat MVR is best avoided.See Commentaries on pages 157, 158, and 160. Hybrid valve-in-valve mitral valve replacement (MVR) may add another option to address the problem of left ventricular outflow tract obstruction in high-risk patients for whom repeat MVR is best avoided. See Commentaries on pages 157, 158, and 160. Valve-in-valve (ViV) transcatheter mitral valve replacement (TMVR) using an Edwards SAPIEN 3 valve (Edwards Lifesciences, Irvine, Calif) has emerged as an alternative for patients at prohibitive risk with reoperation.1Ejiofor J.I. Hirji S.A. Ramirez-Del Val F. Norman A.V. McGurk S. Aranki S.F. et al.Outcomes of repeat mitral valve replacement in patients with prior mitral surgery: a benchmark for transcatheter approaches.J Thorac Cardiovasc Surg. 2018; 156: 619-627.e1Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar,2Shivaraju A. Michel J. Frangieh A.H. Ott I. Thilo C. Schunkert H. et al.Transcatheter aortic and mitral valve-in-valve implantation using the Edwards sapien 3 heart valve.J Am Heart Assoc. 2018; 7: e007767Crossref PubMed Scopus (8) Google Scholar However, iatrogenic left ventricular outflow tract (LVOT) obstruction is a potentially life-threatening complication associated with this technique.3Yoon S.H. Bleiziffer S. Latib A. Eschenbach L. Ancona M. Vincent F. et al.Predictors of left ventricular outflow tract obstruction after transcatheter mitral valve replacement.JACC Cardiovasc Interv. 2019; 12: 182-193Crossref PubMed Scopus (80) Google Scholar ViV-TMVR induced LVOT obstruction occurs when the transcatheter valve metal frame pushes the anterior leaflet of a bioprosthesis toward the interventricular septum, consequently narrowing the LVOT.3Yoon S.H. Bleiziffer S. Latib A. Eschenbach L. Ancona M. Vincent F. et al.Predictors of left ventricular outflow tract obstruction after transcatheter mitral valve replacement.JACC Cardiovasc Interv. 2019; 12: 182-193Crossref PubMed Scopus (80) Google Scholar Hemodynamic instability results due to impediment of blood flow across the LVOT during systole.3Yoon S.H. Bleiziffer S. Latib A. Eschenbach L. Ancona M. Vincent F. et al.Predictors of left ventricular outflow tract obstruction after transcatheter mitral valve replacement.JACC Cardiovasc Interv. 2019; 12: 182-193Crossref PubMed Scopus (80) Google Scholar Preoperative computed tomography–based simulation can identify patients at increased anatomical risk for LVOT obstruction.3Yoon S.H. Bleiziffer S. Latib A. Eschenbach L. Ancona M. Vincent F. et al.Predictors of left ventricular outflow tract obstruction after transcatheter mitral valve replacement.JACC Cardiovasc Interv. 2019; 12: 182-193Crossref PubMed Scopus (80) Google Scholar Predicted neo-LVOT area ≤1.7 cm2 carries high sensitivity and specificity for postprocedural LVOT obstruction.3Yoon S.H. Bleiziffer S. Latib A. Eschenbach L. Ancona M. Vincent F. et al.Predictors of left ventricular outflow tract obstruction after transcatheter mitral valve replacement.JACC Cardiovasc Interv. 2019; 12: 182-193Crossref PubMed Scopus (80) Google Scholar We report a case in which a patient at high risk for redo mitral valve replacement (MVR) and LVOT obstruction with ViV-TMVR instead underwent a hybrid transatrial approach with cardiopulmonary bypass (CBP). This technique allows for resection of previously placed bioprosthetic leaflets and reduces the risk of neo-LVOT obstruction posed by ViV-TMVR. A 71-year-old female patient with severe bioprosthetic mitral stenosis was evaluated by the structural heart team. Nine years previously, she underwent MVR with a 29-mm Edwards Magna Ease bioprosthetic valve (Edwards Lifesciences) via minimally invasive right thoracotomy. Her operation was complicated by failed repair necessitating valve replacement. The initial operation and follow-up occurred at the referring hospital. Her Society of Thoracic Surgeons score was 3.5%. However, her Charlson Comorbidity Index of 6 and Katz Index of 2 of 6 indicated she was frail, deeming her high risk for reoperative MVR. She was considered for ViV-TMVR but preoperative TMVR computed tomography revealed a projected neo-LVOT area of 0.46 cm2 with a 29-mm SAPIEN 3 (Figure 1, A). ViV-TMVR would have resulted in near-total obliteration of her LVOT at end-systole (Figure 1, B). Due to her high-risk nature and concerns for prolonged cardiopulmonary bypass (CPB) required for repeat MVR, we elected to proceed with a hybrid approach via median sternotomy that allowed for resection of the anterior bioprosthetic leaflets before ViV-MVR. Following median sternotomy, CPB was established with aortic and bicaval cannulation. After diastolic arrest, the mitral valve was exposed via Sondergaard's groove. Using a nerve hook pierced through the leaflets of the old bioprosthetic valve, we excised the 2 leaflets adjacent to the LVOT with a #11 blade, thereby mitigating the risk of ViV-MVR induced LVOT obstruction (Video 1). Then, a 29-mm SAPIEN 3 valve was introduced into the mitral annulus over a wire to reduce the risk of left ventricular perforation. Under direct vision, the valve was advanced until the annular sealing cuff was just visible to ensure atrial positioning during deployment. The shaft of the delivery system was adjusted with forceps to ensure perpendicular orientation in relation to the deteriorated surgical valve. The balloon was slowly inflated until the transcatheter valve was secured within the ring of the old prosthesis. Postprocedural saline test confirmed leaflet closure and valve competence. CPB and crossclamp times were 60 and 35 minutes, respectively. Intraoperative transesophageal echocardiogram demonstrated satisfactory mitral valve positioning with no paravalvular leak or significant LVOT gradient. The patient's postoperative course was uneventful, and she was discharged on postoperative day 8. Transthoracic echocardiogram at 30-day follow-up showed a well-functioning bioprosthetic mitral valve with no paravalvular leak or LVOT obstruction (Figure 2). The mean gradient and peak velocity across the mitral valve were 5 mm Hg and 1.1 m/s, respectively. The mean gradient across the LVOT was 7 mm Hg with a maximum velocity of 1.3 m/s. ViV-TMVR is a viable alternative for patients at elevated risk for repeat MVR.2Shivaraju A. Michel J. Frangieh A.H. Ott I. Thilo C. Schunkert H. et al.Transcatheter aortic and mitral valve-in-valve implantation using the Edwards sapien 3 heart valve.J Am Heart Assoc. 2018; 7: e007767Crossref PubMed Scopus (8) Google Scholar LVOT obstruction, however, is a feared complication associated with high mortality rates.3Yoon S.H. Bleiziffer S. Latib A. Eschenbach L. Ancona M. Vincent F. et al.Predictors of left ventricular outflow tract obstruction after transcatheter mitral valve replacement.JACC Cardiovasc Interv. 2019; 12: 182-193Crossref PubMed Scopus (80) Google Scholar Intentional transcatheter laceration of the anterior mitral valve leaflet to prevent LVOT obstruction (LAMPOON) with radiofrequency energy and transapical balloon-assisted translocation of the mitral anterior leaflet (BATMAN) techniques have proven feasible in preventing this problem but have yet to be replicated in larger series.4Khan J.M. Babaliaros V.C. Greenbaum A.B. Foerst J.R. Yazdani S. McCabe J.M. et al.Anterior leaflet laceration to prevent ventricular outflow tract obstruction during transcatheter mitral valve replacement.J Am Coll Cardiol. 2019; 73: 2521-2534Crossref PubMed Scopus (66) Google Scholar,5Helmy T. Hui D.S. Smart S. Lim M.J. Lee R. Balloon assisted translocation of the mitral anterior leaflet to prevent left ventricular outflow obstruction (BATMAN): a novel technique for patients undergoing transcatheter mitral valve replacement.Catheter Cardiovasc Interv. 2020; 95: 840-848Crossref PubMed Scopus (1) Google Scholar The hybrid approach described herein takes advantage of transcatheter valve replacement with short CPB time while allowing for resection of bioprosthetic leaflets to minimize the danger of LVOT obstruction. This technique also obviates the need to resect the ring of an old bioprosthesis, potentially reducing the risk of permanent pacemaker placement or injury to the circumflex artery associated with repeat MVR.1Ejiofor J.I. Hirji S.A. Ramirez-Del Val F. Norman A.V. McGurk S. Aranki S.F. et al.Outcomes of repeat mitral valve replacement in patients with prior mitral surgery: a benchmark for transcatheter approaches.J Thorac Cardiovasc Surg. 2018; 156: 619-627.e1Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar A limitation of the procedure is the need for CPB, which may exclude applicability to extreme-risk patients. In conclusion, hybrid ViV-MVR adds another option to address the problem of LVOT obstruction in high-risk patients for whom repeat MVR is best avoided. eyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiJmOWIwOTljZjM0N2Y2OGJlYWJhYzlhMWU0ODZlMTYzYyIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjM3MTAwMTgxfQ.NTsfO0811CC6V4sXldV4yt0Rm77hnpGaI-2yNlx9GkLoKGLuJabHuSpyk1TRA7AiDSXdnFTmOV8bzmuCxa3aHqIhC_VCkDYnLGNJn_ZZaiEsDXvjqhx_3Yy8OqYCt_yNwajltzGFlrs8wppW3cCp8XbSqCtn6TGEcyTRQBSBysjBmRqrMtdoDK9SAe6Fyx8nb9H2hK3iOJUwyEbqYs1HZ8vJejdMvXfp07_sLgMFRxKugOuKMPE4TE0Up-iDt3qlHq62pBaxtjajY2S2YNmm379WHcGZmoq1iiRzzUsEFiArWxC3H5cDjvR-RkpTPe--uh4m8KOeCEcn_X9lycDEuw Download .mp4 (23.97 MB) Help with .mp4 files Video 1After establishing cardiopulmonary bypass and arresting the heart, the mitral valve was exposed through Sondergaard's groove. The 2 bioprosthetic leaflets of the indwelling 29-mm Edwards valve adjacent to the LVOT were excised with a #11 blade. This maneuver was performed to mitigate the risk of LVOT obstruction after ViV TMVR deployment. A 29-mm SAPIEN 3 valve was introduced into the mitral valve annulus over a wire. Under direct vision, the balloon was slowly inflated until the valve was properly secured within the confines of the mitral annulus. Postprocedural saline test confirmed leaflet closure and valve competence. Bypass and crossclamp times were 60 and 35 minutes, respectively. Intraoperative TEE demonstrated successful mitral valve positioning with no paravalvular leak or significant gradient across the LVOT. Video available at: https://www.jtcvs.org/article/S2666-2507(20)30317-5/fulltext. Download .jpg (.04 MB) Help with files Video 1After establishing cardiopulmonary bypass and arresting the heart, the mitral valve was exposed through Sondergaard's groove. The 2 bioprosthetic leaflets of the indwelling 29-mm Edwards valve adjacent to the LVOT were excised with a #11 blade. This maneuver was performed to mitigate the risk of LVOT obstruction after ViV TMVR deployment. A 29-mm SAPIEN 3 valve was introduced into the mitral valve annulus over a wire. Under direct vision, the balloon was slowly inflated until the valve was properly secured within the confines of the mitral annulus. Postprocedural saline test confirmed leaflet closure and valve competence. Bypass and crossclamp times were 60 and 35 minutes, respectively. Intraoperative TEE demonstrated successful mitral valve positioning with no paravalvular leak or significant gradient across the LVOT. Video available at: https://www.jtcvs.org/article/S2666-2507(20)30317-5/fulltext.