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Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise

2020; Cell Press; Volume: 181; Issue: 7 Linguagem: Inglês

10.1016/j.cell.2020.06.004

1097-4172

James Sanford, Christopher D. Nogiec, Maléne E. Lindholm, Joshua Adkins, David Amar, Surendra Dasari, Jonelle K. Drugan, Facundo M. Fernández, Shlomit Radom‐Aizik, Simon Schenk, M Snyder, Russell P. Tracy, Patrick M. Vanderboom, Scott Trappe, Martin J. Walsh, Joshua Adkins, David Amar, Surendra Dasari, Jonelle K. Drugan, Charles R. Evans, Facundo M. Fernández, Yafeng Li, Maléne E. Lindholm, Christopher D. Nogiec, Shlomit Radom‐Aizik, James Sanford, Simon Schenk, M Snyder, Lyl Tomlinson, Russell P. Tracy, Scott Trappe, Patrick M. Vanderboom, Martin J. Walsh, D. Lee Alekel, Iddil Bekirov, Amanda Boyce, Josephine Boyington, Jerome L. Fleg, Lyndon Joseph, Maren R. Laughlin, Padma Maruvada, Stephanie A. Morris, Joan McGowan, Concepcion R. Nierras, Vinay Pai, Charlotte A. Peterson, Ed Ramos, Mary Roary, John Williams, Ashley Xia, Elaine Cornell, Jessica L. Rooney, Michael E. Miller, Walter T. Ambrosius, Scott Rushing, Cynthia L. Stowe, W. Jack Rejeski, Barbara J. Nicklas, Marco Pahor, Ching-ju Lu, Todd A. Trappe, Toby L. Chambers, Ulrika Raue, Bridget Lester, Bryan C. Bergman, David H. Bessesen, Catherine M. Jankowski, Wendy M. Kohrt, Edward L. Melanson, Kerrie L. Moreau, Irene E. Schauer, Robert S. Schwartz, William E. Kraus, Cris A. Slentz, Kim M. Huffman, Johanna L. Johnson, Leslie H. Willis, Leslie Kelly, Joseph A. Houmard, Gabriel S. Dubis, Nicholas T. Broskey, Bret H. Goodpaster, Lauren M. Sparks, Paul M. Coen, Dan M. Cooper, Fadia Haddad, Tuomo Rankinen, Éric Ravussin, Neil M. Johannsen, Melissa Harris, John M. Jakicic, Anne B. Newman, Daniel D. Forman, Erin E. Kershaw, Renee J. Rogers, Bradley C. Nindl, Lindsay Page, Maja Stefanović-Račić, Susan L. Barr, Blake B. Rasmussen, Tatiana Moro, Douglas Paddon‐Jones, Elena Volpi, Heidi Spratt, Nicolas Musi, Sara Espinoza, D.C. Patel, Monica C. Serra, Jonathan Gelfond, Aisling Burns, Marcas M. Bamman, Thomas W. Buford, Gary Cutter, Sue C. Bodine, Karyn A. Esser, Rodger P. Farrar, Laurie J. Goodyear, Michael F. Hirshman, Brent G. Albertson, Weijun Qian, Paul Piehowski, Marina Gritsenko, Matthew E. Monore, Vladislav Petyuk, Jason McDermott, Joshua Hansen, Chelsea Hutchison, Samuel Moore, David A. Gaul, Clary B. Clish, Julián Ávila-Pacheco, Courtney Dennis, Manolis Kellis, Steve Carr, Pierre M. Jean-Beltran, Hasmik Keshishian, DR Mani, Karl R. Clauser, Karsten Krug, Charlie Mundorff, Cadence Pearce, Anna Ivanova, Eric A. Ortlund, Kristal Maner-Smith, Karan Uppal, Tiantian Zhang, Stuart C. Sealfon, Elena Zaslavsky, Venugopalan D. Nair, SiDe Li, Nimisha Jain, Yongchao Ge, Yifei Sun, German Nudelman, Frederique Ruf-Zamojski, Gregory R. Smith, Nhanna Pincas, Aliza B. Rubenstein, Mary Anne S. Amper, Nitish Seenarine, Tuuli Lappalainen, Ian R. Lanza, K. Sreekumaran Nair, Katherine A. Klaus, Stephen B. Montgomery, Kevin S. Smith, Nicole R. Gay, Bingqing Zhao, Chia-Jiu Hung, Navid Zebarjadi, Brunilda Balliu, Laure Frésard, Charles Burant, Jun Z. Li, Maureen Kachman, Tanu Soni, Alexander Raskind, Robert Gerszten, Jeremy Robbins, Olga Ilkayeva, Michael J. Muehlbauer, Christopher B. Newgard, Euan A. Ashley, Matthew T. Wheeler, David Jimenez‐Morales, Archana N. Raja, Karen Dalton, Jimmy Zhen, Young Suk Kim, Jeffrey W. Christle, Shruti Marwaha, Elizabeth T. Chin, Steven G. Hershman, Trevor Hastie, Robert Tibshirani, Manuel A. Rivas,

Muscle metabolism and nutrition

Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease. Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.