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A prospect on the use of antiviral drugs to control local outbreaks of COVID-19

2020; BioMed Central; Volume: 18; Issue: 1 Linguagem: Inglês

10.1186/s12916-020-01636-4

1741-7015

Andrea Torneri, Pieter Libin, Joris Vanderlocht, Anne–Mieke Vandamme, Johan Neyts, Niel Hens,

COVID-19 Clinical Research Studies

Current outbreaks of COVID-19 are threatening the health care systems of several countries around the world. Control measures, based on isolation, contact tracing, and quarantine, can decrease and delay the burden of the ongoing epidemic. With respect to the ongoing COVID-19 epidemic, recent modeling work shows that these interventions may be inadequate to control local outbreaks, even when perfect isolation is assumed. The effect of infectiousness prior to symptom onset combined with asymptomatic infectees further complicates the use of contact tracing. We aim to study whether antivirals, which decrease the viral load and reduce infectiousness, could be integrated into control measures in order to augment the feasibility of controlling the epidemic.