Does SARS-CoV-2 Trigger Stress-Induced Autoimmunity by Molecular Mimicry? A Hypothesis
2020; Multidisciplinary Digital Publishing Institute; Volume: 9; Issue: 7 Linguagem: Inglês
10.3390/jcm9072038
ISSN2077-0383
AutoresFrancesco Cappello, Antonella Marino, Francesco Dieli, Everly Conway de Macario, Alberto J.L. Macario,
Tópico(s)Viral gastroenteritis research and epidemiology
ResumoViruses can generate molecular mimicry phenomena within their hosts. Why shouldsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) not be considered one of these?Information in this short review suggests that it might be so and, thus, encourages research aimingat testing this possibility. We propose, as a working hypothesis, that the virus induces antibodiesand that some of them crossreact with host's antigens, thus eliciting autoimmune phenomena withdevasting consequences in various tissues and organs. If confirmed, by in vitro and in vivo tests,this could drive researchers to find effective treatments against the virus.
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