Produção Nacional
Revisado por pares
Naturally Acquired Humoral Immunity against Malaria Parasites in Non-Human Primates from the Brazilian Amazon, Cerrado and Atlantic Forest
2020; Multidisciplinary Digital Publishing Institute; Volume: 9; Issue: 7 Linguagem: Inglês
10.3390/pathogens9070525
ISSN2076-0817
AutoresEliana Ferreira Monteiro, Carmen Fernández-Becerra, Maísa da Silva Araújo, Mariluce Rezende Messias, Luiz S. Ozaki, Ana Maria Ribeiro de Castro Duarte, Marina Galvão Bueno, José Luiz Catão‐Dias, Carolina Romeiro Fernandes Chagas, Bruno S. Mathias, Mayra Gomes Dos Santos, Stéfanie Vanessa Santos, Márcia Moreira Holcman, Júlio César de Souza, Karin Kirchgatter,
Tópico(s)Primate Behavior and Ecology
ResumoNon-human primates (NHPs) have been shown to be infected by parasites of the genus Plasmodium, the etiological agent of malaria in humans, creating potential risks of zoonotic transmission. Plasmodium brasilianum, a parasite species similar to P. malariae of humans, have been described in NHPs from Central and South America, including Brazil. The merozoite surface protein 1 (MSP1), besides being a malaria vaccine candidate, is highly immunogenic. Due to such properties, we tested this protein for the diagnosis of parasite infection. We used recombinant proteins of P. malariae MSP1, as well as of P. falciparum and P. vivax, for the detection of antibodies anti-MSP1 of these parasite species, in the sera of NHPs collected in different regions of Brazil. About 40% of the NHP sera were confirmed as reactive to the proteins of one or more parasite species. A relatively higher number of reactive sera was found in animals from the Atlantic Forest than those from the Amazon region, possibly reflecting the former more intense parasite circulation among NHPs due to their proximity to humans at a higher populational density. The presence of Plasmodium positive NHPs in the surveyed areas, being therefore potential parasite reservoirs, needs to be considered in any malaria surveillance program.
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