Portal de Periódicos da CAPES

PP.23.07

2015; Lippincott Williams & Wilkins; Volume: 33; Issue: Supplement 1 Linguagem: Inglês

10.1097/01.hjh.0000468420.76646.66

1473-5598

Jae K. Oh, Hairong Yu, Seong Lyul Park, Euichan Shin, Jong‐Chan Youn, S. Lee, Sora Kang, Doo Hong Choi,

Atherosclerosis and Cardiovascular Diseases

Objective: T-cell mediated immune responses play important roles in the progression of atherosclerotic disease and hypertension. Studies have linked various inflammatory biomarkers with hypertension, but the significance of T-cell specific chemokines in arterial stiffness has not been confirmed. Herein, we sought to examine the association between serum levels of the monokine induced by gamma interferon (MIG) and arterial stiffness in Korean community. Design and method: The MIG were measured in 456 subjects (66 ± 6 years old, 31.6% males, 52.1% hypertension, 11.6% diabetes mellitus, body mass index 25.2 ± 2.9 kg/m2) who enrolled in Mapo-gu community cohort in Seoul. Arterial stiffness parameters were assessed via pulse wave analysis of the radial artery. Results: Mean concentrations of MIG was 141.2 ± 116.4 pg/mL and mean brachial to ankle PWV (baPWV) was 1631 ± 281 cm/s. There was a significant correlation between MIG and baPWV (r = 0.158, p = 0.001) and this correlation was significant after adjusting age, gender, body mass index (BMI), systolic blood pressure (SBP) and heart rate (HR) (r = 0.176, p < 0.001). Multiple linear regression analysis revealed that serum MIG levels were independently associated with baPWV when controlled for confounding factors including age, gender, SBP, HR, BMI, glucose, triglyceride, high sensitive C-reactive protein, hypertension, diabetes mellitus, hyperlipidemia history and hypertension medications (β=0.148, p < 0.001, R2 = 0.381). Conclusions: Serum MIG levels are independently associated with arterial stiffness after adjustment for traditional cardiovascular risk factors. These findings suggest that MIG may be used as a novel biomarker for vascular disease such as atherosclerosis and hypertension in humans.