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Definition and Risks of Cytokine Release Syndrome in 11 Critically Ill COVID-19 Patients With Pneumonia: Analysis of Disease Characteristics

2020; Oxford University Press; Volume: 222; Issue: 9 Linguagem: Inglês

10.1093/infdis/jiaa387

1537-6613

Wenjun Wang, Xiaoqing Liu, Si-Pei Wu, Sibei Chen, Yimin Li, Lingbo Nong, Puyi Lie, Liyan Huang, Linling Cheng, Yongping Lin, Jianxing He,

Intensive Care Unit Cognitive Disorders

Corona virus disease 2019 (COVID-19) patients with severe immune abnormalities are at risk of cytokine release syndrome (CRS). The definition, prevention, and treatment of symptoms of CRS in critically ill patients with COVID-19 are important problems. We report a single-center case series of 11 COVID-19 patients with acute respiratory distress syndrome from The First Affiliated Hospital of Guangzhou Medical University in China from 26 January 2020 to 18 February 2020. The termination date of follow-up was 19 February 2020. Eight patients were determined to have characteristics of CRS, including pulmonary inflammation, fever, and dysfunction of nonpulmonary organs. An increase in interleukin-6 in peripheral blood was the highest risk factor and an early indicator of CRS in COVID-19.