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Fatal underhanded chronic enterovirus infection associated with anti-CD20 monotherapy for central nervous system demyelinating disease

2020; SAGE Publishing; Volume: 27; Issue: 2 Linguagem: Inglês

10.1177/1352458520923978

1477-0970

Léa Luciani, Läétitia Ninove, Christine Zandotti, Virginie Chalvignac, David Lagier, Julien Baume, Julien Mélade, Géraldine Piorkowski, Bruno Coutard, Hubert Lépidi, Jean Pelletier, Bertrand Audoin, Audrey Rico-Lamy, Antoine Nougairède,

RNA Research and Splicing

We report a fatal case of coxsackievirus B4 chronic infection in a 30-year-old woman with a diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disorder controlled by rituximab monotherapy for 3 years. Initially presenting as self-limited meningitis, the infection remained silent for 8 months before the sudden onset of fulminant myocarditis. Analysis of the complete genome showed that the same virus was responsible for both episodes.