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Remaining kidney volume indexed to weight as a strong predictor of estimated glomerular filtration rate at 1 year and mid‐term renal function after living‐donor nephrectomy ‐ a retrospective observational study

2020; Springer Science+Business Media; Volume: 33; Issue: 10 Linguagem: Inglês

10.1111/tri.13683

1432-2277

Diogo Nunes‐Carneiro, Mariana Madanelo, Filipa Silva, Nicole Pestana, Catarina Ribeiro, Diogo Gil‐Sousa, La Salete Martins, Manuela Almeida, Leonídio Dias, Jorge Malheiro, Vítor Cavadas, António Castro‐Henriques, Avelino Fraga, Miguel Silva‐Ramos,

Dialysis and Renal Disease Management

The donors' estimated glomerular filtration rate (eGFR) after living nephrectomy has been a concern, particularly in donors with smaller kindeys.Therefore, we developed this retrospective observational study in 195 donors to determine the ability remaining kidney volume indexed to weight (RKV/W) to predict eGFR at 1 year through multivariate linear regression and to explore this relationship between annual eGFR change from 1 to 4 years postdonation evaluated by a linear mixed model.Comparing RKV/W tertiles (T1, T2, T3), RKV/W was a good predictor of 1year eGFR which was significantly better in T3 donors.Gender, predonation eGFR, and RKV/W were independent predictors of eGFR at 1-year.In a subgroup with predonation eGFR < 90mL/min/1.73 m 2 , a significant prediction of eGFR < 60mL/min/1.73 m 2 was detected in males with RKV/ W ≤ 2.51cm 3 /kg.Annual eGFR (ml/min/year) change from 1 to 4 years was + 0.77.RKV/W divided by tertiles (T1-T3) was the only significant predictor: T2 and T3 donors had an annual eGFR improvement opposing to T1. RKV/W was a good predictor of eGFR at 1 year, independently from predonation eGFR.A higher RKV/W was associated with improved eGFR at 1 year.A decline in eGFR on the four years after surgery was only noticeable in donors with RKV/W ≤ 2.13cm 3 /kg.