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Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear

2020; Cell Press; Volume: 182; Issue: 4 Linguagem: Inglês

10.1016/j.cell.2020.06.040

1097-4172

Nathan D. Grubaugh, William P. Hanage, Angela L. Rasmussen,

Viral Infections and Outbreaks Research

In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely unknown. In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely unknown.