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Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats

2020; Wiley; Volume: 236; Issue: 2 Linguagem: Inglês

10.1002/jcp.29919

1097-4652

Olívia Moraes Ruberti, Andressa Silva Sousa, Laís Rosa Viana, Moisés Felipe Pereira Gomes, Alessandra Medeiros, Maria Cristina Cintra Gomes‐Marcondes, Luciano de Figueiredo Borges, Carlos C. Crestani, Cristiano Teixeira Mostarda, Telma F. Cunha, Rafael Renatino Canevarolo, Maria Andréia Delbin, Bruno Rodrigues,

Heart Rate Variability and Autonomic Control

Abstract This study aimed to evaluate the impact of aerobic training (AT) on autonomic, cardiometabolic, ubiquitin‐proteasome activity, and inflammatory changes evoked by myocardial infarction (MI) in ovariectomized rats. Female Wistar rats were ovariectomized and divided into four groups: sedentary + sham (SS), sedentary + MI (SI), AT + sham surgery (TS), AT + MI (TI). AT was performed on a treadmill for 8 weeks before MI. Infarcted rats previously subjected to AT presented improved physical capacity, increased interleukin‐10, and decreased pro‐inflammatory cytokines. Metabolomic analysis identified and quantified 62 metabolites, 9 were considered significant by the Vip Score. SS, SI, and TS groups presented distinct metabolic profiles; however, TI could not be distinguished from the SS group. MI dramatically increased levels of dimethylamine, and AT prevented this response. Our findings suggest that AT may be useful in preventing the negative changes in functional, inflammatory, and metabolic parameters related to MI in ovariectomized rats.