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Circulating Folate and Folic Acid Concentrations: Associations With Colorectal Cancer Recurrence and Survival

2020; Oxford University Press; Volume: 4; Issue: 5 Linguagem: Inglês

10.1093/jncics/pkaa051

2515-5091

Anne J. M. R. Geijsen, Arve Ulvik, Biljana Gigic, Dieuwertje E. Kok, Fränzel J.B. van Duijnhoven, Andreana N. Holowatyj, Stefanie Brezina, Eline H. van Roekel, Andreas Baierl, Michael Bergmann, Jürgen Böhm, Martijn J.L. Bours, Hermann Brenner, Stéphanie O. Breukink, Mary P. Bronner, Jenny Chang‐Claude, Johannes H.W. de Wilt, William M. Grady, Thomas Grünberger, Tanja Gumpenberger, Esther Herpel, Michael Hoffmeister, Lyen C. Huang, Jolanta Jedrzkiewicz, Eric T.P. Keulen, Rama Kiblawi, Torsten Kölsch, Janna L. Koole, Katharina Kosma, Ewout A. Kouwenhoven, Flip M. Kruyt, Gry Kvalheim, Christopher I. Li, Tengda Lin, Jennifer Ose, T. Bartley Pickron, Courtney L. Scaife, Peter Schirmacher, Martin Schneider, Petra Schrotz‐King, Marie C Singer, Eric R. Swanson, Peter van Duijvendijk, Henk K. van Halteren, Moniek van Zutphen, Kathy Vickers, F. Jeroen Vogelaar, Evertine Wesselink, James E. Haber, Alexis Ulrich, Per Magne Ueland, Matty P. Weijenberg, Andrea Gsur, Cornelia M. Ulrich, Ellen Kampman,

Nutrition and Health in Aging

Folates, including folic acid, may play a dual role in colorectal cancer development. Folate is suggested to be protective in early carcinogenesis but could accelerate growth of premalignant lesions or micrometastases. Whether circulating concentrations of folate and folic acid, measured around time of diagnosis, are associated with recurrence and survival in colorectal cancer patients is largely unknown.