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Enanthem in Patients With COVID-19 and Skin Rash

2020; American Medical Association; Volume: 156; Issue: 10 Linguagem: Inglês

10.1001/jamadermatol.2020.2550

2168-6084

Juan ­Jimenez‐Cauhe, ­Daniel ­Ortega‐Quijano, Dario de Perosanz‐Lobo, Patrícia Burgos‐Blasco, Sergio Vañó‐Galván, Montse Fernández‐Guarino, Diego Fernández‐Nieto,

Streptococcal Infections and Treatments

Figure 1).Their HAP scores gradually increased, and the hypotrichosis in the patient with TRPS1 did not improve (Figure 2A).Hair shaft diameters were increased in every participant with LIPH pathogenic variants (Figure 2B andC).There were no serious adverse events, but some mild adverse events were reported (dry skin on the scalp, trichiasis, and mild hypertrichosis on the entire body).Discussion | Lysophosphatidic acids bind the P2Y5 receptor in the hair follicle epithelium and activate hair growth. 5In ARWH due to LIPH pathogenic variants, loss-of-function variants in LIPH lead to a deficiency of lysophosphatidic acids and insufficient activation of P2Y5.The present prospective interventional study suggests that minoxidil could be associated with improvements in hypotrichosis in ARWH owing to LIPH pathogenic variants.There appears to be a binary response to minoxidil, with one group responding better than the other.The data on causative pathogenic variants suggest that it is unrelated to the LIPH pathogenic variants.Among the 8 patients with ARWH due to LIPH pathogenic variants, 5 patients were unrelated, and the other 3 were from 1 family.All 3 members of the family were in the group responding better.Thus, we cannot exclude the possibility that the family had an unknown genetic modifying factor affecting the efficacy of minoxidil.