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Design of ellagic acid-loaded chitosan/zein films for wound bandaging

2020; Elsevier BV; Volume: 59; Linguagem: Inglês

10.1016/j.jddst.2020.101903

2588-8943

Walter S. Tavares, Alberto Gomes Tavares, Francisco J. Otero‐Espinar, Manuel Martín‐Pastor, Francisco Fábio Oliveira de Sousa,

Nanocomposite Films for Food Packaging

Chitosan/zein films were developed for controlled release of ellagic acid using a central composite design to evaluate the effect of the polymers concentration on the films’ characteristics and its application as a wound bandaging platform. The films’ characteristics were predicted with quadratic models. Responses were found to depend on the composition of the film, with both polymers exerting a significant influence on the resulting thickness and contact angle (p < 0.05). Zein presented a significant influence on the release of ellagic acid. Furthermore, the obtained films presented suitable thickness, high sorption and controlled release pattern. Most films presented inhibitory activity against Staphylococcus aureus and Pseudomonas aeruginosa in vitro, supporting their use as a bandaging platform with antimicrobial features. These results show that the polymeric films prepared could become a therapeutic option to prevent/treat cutaneous-mucous infections and to aid on the skin rehabilitation.