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Clinical presentation and outcome across age categories among patients with COVID-19 admitted to a Spanish Emergency Department

2020; Elsevier BV; Volume: 11; Issue: 5 Linguagem: Inglês

10.1007/s41999-020-00359-2

1878-7657

Francisco Javier Martín‐Sánchez, Enrique del Toro, Eduardo Bajo Cardassay, Adrián Valls Carbó, Federico Cuesta, Marta Vigara, Pedro Gil Madrona, Amanda López Picado, Carmen Martínez-Valero, Juan de Dios Miranda, Pedro López‐Ayala, David Chaparro, Gabriel Cozar López, María del Mar Suárez-Cadenas, Pablo Jerez-Fernández, Beatriz Angós, Cristina Díaz del Arco, Esther Rodríguez Adrada, María Teresa Montalvo Moraleda, Carolina Espejo Paeres, Cesáreo Fernández Alonso, Carlos Lerma, Ana Chacón, Miguel Ángel García Briñón, José Luis Fernández Rueda, Luís Ortega, Cristina Fernández, Juan Jorge González Armengol, Juan González del Castillo,

Long-Term Effects of COVID-19

To determine the differences by age-dependent categories in the clinical profile, presentation, management, and short-term outcomes of patients with laboratory-confirmed COVID-19 admitted to a Spanish Emergency Department (ED).Secondary analysis of COVID-19_URG-HCSC registry. We included all consecutive patients with laboratory-confirmed COVID-19 admitted to the ED of the University Hospital Clinico San Carlos (Madrid, Spain). The population was divided into six age groups. Demographic, baseline and acute clinical data, and in-hospital and 30-day outcomes were collected.1379 confirmed COVID-19 cases (mean age 62 (SD 18) years old; 53.5% male) were included (18.1% < 45 years; 17.8% 45-54 years; 17.9% 55-64 years; 17.2% 65-74 years; 17.0% 75-84 years; and 11.9% ≥ 85 years). A statistically significant association was found between demographic, comorbidity, clinical, radiographic, analytical, and therapeutic variables and short-term results according to age-dependent categories. There were less COVID-specific symptoms and more atypical symptoms among older people. Age was a prognostic factor for hospital admission (aOR = 1.04; 95% CI 1.02-1.05) and in-hospital (aOR = 1.08; 95% CI 1.05-1.10) and 30-day mortality (aOR = 1.07; 95% CI 1.04-1.09), and was associated with not being admitted to intensive care (aOR = 0.95; 95% CI 0.93-0.98).Older age is associated with less COVID-specific symptoms and more atypical symptoms, and poor short-term outcomes. Age has independent prognostic value and may help in shared decision-making in patients with confirmed COVID-19 infection.